2024
Mosunetuzumab with Response-Driven Lenalidomide Augmentation As First-Line Therapy for Symptomatic Follicular or Marginal Zone Lymphoma: Interim Analysis of a Multi-Center Phase 2 Study
Olszewski A, Matasar M, Huntington S, Ollila T, Pelcovits A, Tiger Y, Reagan J, Chorzalska A, Morgan J, Pardo M, McMahon J, Donnelly S, Carmody C, Margolis J, Milrod C, Dubielecka P. Mosunetuzumab with Response-Driven Lenalidomide Augmentation As First-Line Therapy for Symptomatic Follicular or Marginal Zone Lymphoma: Interim Analysis of a Multi-Center Phase 2 Study. Blood 2024, 144: 1644. DOI: 10.1182/blood-2024-193022.Peer-Reviewed Original ResearchMarginal zone lymphomaCytokine release syndromeOverall response rateCR rateComplete responseFollicular lymphomaPartial responseOverall survivalAdverse eventsLugano criteriaImmune augmentationEfficacy analysisFirst-line treatment of FLTEMRA CD8+ T cellsCounts of NK cellsTreatment of follicular lymphomaCD8+ T cellsInterim analysisPhase 2 clinical trialCT-based criteriaCytokine release syndrome eventLow-dose lenalidomideStep-up dosingPatients discontinued treatmentPD-1 expressionCirculating Biomarkers and CD8+ T-Cell Subpopulations Reveal Evolving Phases of Immune Response in Patients Receiving Mosunetuzumab for Previously Untreated B-Cell Lymphoma
Milrod C, Chorzalska A, Morgan J, Pardo M, Raker C, Ollila T, Lee S, Pelcovits A, Reagan J, McMahon J, Donnelly S, Carmody C, Margolis J, Matasar M, Huntington S, Dubielecka P, Olszewski A. Circulating Biomarkers and CD8+ T-Cell Subpopulations Reveal Evolving Phases of Immune Response in Patients Receiving Mosunetuzumab for Previously Untreated B-Cell Lymphoma. Blood 2024, 144: 1614-1614. DOI: 10.1182/blood-2024-193023.Peer-Reviewed Original ResearchCD8+ T cellsCD8+ T cell subsetsT cell activationEM CD8+ T cellsB-cell lymphomaT cell subsetsT cellsBsAb therapyComplete responseEffector memoryImmune responseCD8+ T cell activationT cell-engaging therapiesTreatment of B-cell lymphomaCentral memory T cellsT cell activation markersAlternative administration schedulesCD8+T cell activityLow-dose lenalidomidePrior chemotherapy exposureMarginal zone lymphomaT cell exhaustionT-cell engagersAnti-lymphoma activityMemory T cells
2023
Alterations in Immune Cell Composition during First-Line Therapy with Mosunetuzumab for Follicular or Marginal Zone Lymphoma
Olszewski A, Ollila T, Pelcovits A, Chorzalska A, Morgan J, McMahon J, Donnelly S, Huntington S, Matasar M, Reagan J, Milrod C, Dubielecka P. Alterations in Immune Cell Composition during First-Line Therapy with Mosunetuzumab for Follicular or Marginal Zone Lymphoma. Blood 2023, 142: 1651. DOI: 10.1182/blood-2023-181418.Peer-Reviewed Original ResearchEnd of therapyCytokine release syndromeMarginal zone lymphomaT cellsComplete responsePD1 expressionNK cellsB cellsEffector memory T cellsCheckpoint inhibitor combinationsExpression of LAG3Immune cell changesB-cell depletionFirst-line therapyExpansion of TregsT cell exhaustionMemory T cellsPrior chemotherapy exposureImmune cell subsetsImmune cell compositionPeripheral blood samplesMulticolor flow cytometrySignificant increaseTreatment-induced changesExhausted phenotypeA phase 2 trial of mosunetuzumab with lenalidomide augmentation as first-line therapy for follicular (FL) and marginal zone lymphoma (MZL).
Olszewski A, Huntington S, Ollila T, Pelcovits A, McMahon J, Yakirevich I, Sturtevant A, Chorzalska A, Morgan J, Dubielecka P. A phase 2 trial of mosunetuzumab with lenalidomide augmentation as first-line therapy for follicular (FL) and marginal zone lymphoma (MZL). Journal Of Clinical Oncology 2023, 41: tps7588-tps7588. DOI: 10.1200/jco.2023.41.16_suppl.tps7588.Peer-Reviewed Original ResearchMarginal zone lymphomaCytokine release syndromeFirst-line therapyCR rateT cell-engaging bispecific antibodiesFirst-line systemic therapyCytotoxic T cell responsesLow-dose lenalidomideComplete response rateFirst-line treatmentLines of therapyPhase 2 trialT-cell depletionT cell immunityT cell responsesHost immune environmentRate of progressionRates of toxicityNovel therapeutic approachesHigh-burden diseasesImmunosuppressive modalitiesRefractory FLRelease syndromeStable diseaseStudy therapy
2022
Mosunetuzumab with Lenalidomide Augmentation As First-Line Therapy for Follicular (FL) and Marginal Zone Lymphoma (MZL)
Olszewski A, Huntington S, Bannerji R, Ollila T, McMahon J, Dubielecka P. Mosunetuzumab with Lenalidomide Augmentation As First-Line Therapy for Follicular (FL) and Marginal Zone Lymphoma (MZL). Blood 2022, 140: 6492-6493. DOI: 10.1182/blood-2022-157463.Peer-Reviewed Original Research