2024
Phase 1 Study of ARV-393, a PROTAC BCL6 Degrader, in Advanced Non-Hodgkin Lymphoma
Caimi P, Huntington S, Landrette S, Gough S, Dai V, Jackson B, Yu T, Chavez J, Tannenbaum-Dvir S, Matasar M. Phase 1 Study of ARV-393, a PROTAC BCL6 Degrader, in Advanced Non-Hodgkin Lymphoma. Blood 2024, 144: 6505. DOI: 10.1182/blood-2024-208356.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaB-cell non-Hodgkin lymphomaDiffuse large B-cell lymphomaStem cell transplantationPhase 1 studyCell transplantationAdvanced B-cell non-Hodgkin's lymphomaB cellsMature B-cell non-Hodgkin lymphomaXenograft models of non-Hodgkin lymphomaBCL6 expressionEastern Cooperative Oncology Group performance statusModel of non-Hodgkin lymphomaAdvanced non-Hodgkin's lymphomaAllogeneic stem cell transplantationAngioimmunoblastic T-cell lymphomaAutologous stem cell transplantationLarge B-cell lymphomaNon-Hodgkin's lymphoma casesCell line-derived xenograft modelT follicular helper cellsPatient-derived xenograft modelsStandard of care therapyHigh risk of transformationCentral nervous system involvement
2019
AG-636 for the Treatment of Adults with Advanced Lymphoma: Initiation of a Phase 1 Clinical Study
Huntington S, Kallam A, Basile F, Ulanet D, Xu H, Yin F, Mobilia M, Cooper M, Shah B, Leonard J, von Keudell G, Gopal A. AG-636 for the Treatment of Adults with Advanced Lymphoma: Initiation of a Phase 1 Clinical Study. Blood 2019, 134: 1286. DOI: 10.1182/blood-2019-123420.Peer-Reviewed Original ResearchDose-limiting toxicityDiffuse large B-cellDose-escalation phaseAgios PharmaceuticalsAdvanced lymphomaHematologic malignanciesKaryopharm TherapeuticsSeattle GeneticsEscalation phaseT cellsEastern Cooperative Oncology Group performance statusADC therapeuticsActive central nervous system diseaseAdaptive Bayesian logistic regression modelChimeric antigen receptor T-cell therapyPrior stem cell transplantSerum total bilirubin levelPhase 1 clinical studyCentral nervous system diseaseDose-expansion phaseOptimal starting doseCycles of therapyOpen-label studyAbsolute neutrophil countAdvanced solid tumors