2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Embryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages
2018
Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies
Martin-Lopez E, Meller SJ, Greer CA. Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies. Brain Structure And Function 2018, 223: 4067-4085. PMID: 30141078, PMCID: PMC6252112, DOI: 10.1007/s00429-018-1741-y.Peer-Reviewed Original ResearchConceptsAnterior commissurePostnatal developmentPostnatal day 22Inter-hemispheric connectionsChondroitin sulfate proteoglycanPiriform cortexContralateral innervationGlial cellsOlfactory areasBed nucleusInterhemispheric connectionsStria terminalisDay 22Axonal tractsAxon growthNew subtypeAxon outgrowthCalretininCommissureSulfate proteoglycanAxonsPhenotypeInnervationIpsiImmunohistochemistry