2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2020
AP-1 controls the p11-dependent antidepressant response
Chottekalapanda R, Kalik S, Gresack J, Ayala A, Gao M, Wang W, Meller S, Aly A, Schaefer A, Greengard P. AP-1 controls the p11-dependent antidepressant response. Molecular Psychiatry 2020, 25: 1364-1381. PMID: 32439846, PMCID: PMC7303013, DOI: 10.1038/s41380-020-0767-8.Peer-Reviewed Original ResearchConceptsAP-1 functionSelective serotonin reuptake inhibitorsTranscriptional programsSpecific gene expression programsActivator protein-1 complexGene expression programsAntidepressant responseProtein-1 complexExpression programsMolecular networksC-JunAP-1PI3KExtracellular serotonin levelsSerotonin reuptake inhibitorsC-fosPrecise modeNeuronal plasticitySSRI actionAntidepressant effectsReuptake inhibitorsSSRI responseSerotonin levelsPrescribed drugsTherapeutic effect