2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Sequential Maturation of Olfactory Sensory Neurons in the Mature Olfactory Epithelium
Liberia T, Martin-Lopez E, Meller SJ, Greer CA. Sequential Maturation of Olfactory Sensory Neurons in the Mature Olfactory Epithelium. ENeuro 2019, 6: eneuro.0266-19.2019. PMID: 31554664, PMCID: PMC6795559, DOI: 10.1523/eneuro.0266-19.2019.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsOlfactory epitheliumOSN axonsSensory neuronsBasal cell divisionNew olfactory sensory neuronsYoung adultsMature olfactory epitheliumYoung adult micePostnatal day 25Olfactory bulb glomeruliMolecular maturationFate mapping strategyOlfactory nerveSpecific glomeruliCribriform plateAdult miceGAP-43Day 25Time pointsAxonsOMP expressionOlfactory systemSequential maturationAxon developmentEmbryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages