Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults
Odriozola P, Kribakaran S, Cohodes E, Zacharek S, McCauley S, Haberman J, Quintela L, Hernandez C, Spencer H, Pruessner L, Caballero C, Gee D. Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults. Biological Psychiatry Global Open Science 2023, 4: 155-164. PMID: 38298801, PMCID: PMC10829678, DOI: 10.1016/j.bpsgos.2023.05.007.Peer-Reviewed Original ResearchSafety signal learningDorsal anterior cingulate cortexTrait anxietyFear reductionEffects of noveltyHippocampal activationSignal learningThreat responsesNeural mechanismsAnxiety disordersFunctional connectivityVentrolateral prefrontal cortex activationInhibition of fearLow trait anxietyCross-species evidenceInferior frontal gyrusHigh trait anxietyPrefrontal cortex activationAnterior cingulate cortexHealthy adultsNeural correlatesFrontal gyrusAnterior hippocampusCortex activationHippocampal involvement