Featured Publications
Interrogation of clonal tracking data using barcodetrackR
Espinoza D, Mortlock R, Koelle S, Wu C, Dunbar C. Interrogation of clonal tracking data using barcodetrackR. Nature Computational Science 2021, 1: 280-289. PMID: 37621673, PMCID: PMC10449013, DOI: 10.1038/s43588-021-00057-4.Peer-Reviewed Original ResearchProgenitor cellsClonal tracking studiesProgenitor cell outputContext of genesHSPC transplantCellular compartmentsCellular outputStandardized analytical frameworkLineage relationshipsHematopoietic stemClonal dynamicsHSPC gene therapyLineage reconstitutionR packageVector genotoxicityCellsShiny appTumor cellsClonal patternGene therapyTracking dataDiverse toolsGenesQuantitative insightsValuable insights
2024
Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 788. PMID: 38599215, PMCID: PMC11114628, DOI: 10.1016/j.stem.2024.04.005.Peer-Reviewed Original ResearchImpact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 455-466.e4. PMID: 38508195, PMCID: PMC10997443, DOI: 10.1016/j.stem.2024.02.010.Peer-Reviewed Original ResearchLentiviral vectorsRhesus macaquesGFP-expressing lentiviral vectorsClonal dynamicsLong-term engrafting hematopoietic stem cellsLong-term engraftmentHematopoietic stem cellsAutologous transplantation modelClinically relevant differencesLT-HSCLT-HSCsCells long-termTransplantation modelLentiviral transductionP53 inhibitionAnimal modelsStem cellsGenetic modification approachesRelevant differencesClonalityHSCCellsMacaquesEngraftmentCD33