2019
Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy
Gruenbaum SE, Dhaher R, Rapuano A, Zaveri HP, Tang A, de Lanerolle N, Eid T. Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. Journal Of Neurosurgical Anesthesiology 2019, 31: 247-256. PMID: 29620688, PMCID: PMC6170745, DOI: 10.1097/ana.0000000000000499.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyLobe epilepsySpontaneous seizuresNeuron lossSeizure propagationBranched-chain amino acid supplementationChronic oral supplementationSpontaneous recurrent seizuresEffect of BCAAPotential novel treatmentBranched-chain amino acid leucineAmino acid supplementationAcute seizuresBCAA supplementationChronic seizuresConvulsive seizuresOral supplementationRecurrent seizuresRefractory epilepsyDentate hilusNeuronal viabilityAcid supplementationImmunohistochemical analysisNovel treatments
2017
2092
Gruenbaum S, Dhaher R, Rapuano A, Eid T. 2092. Journal Of Clinical And Translational Science 2017, 1: 56-56. PMCID: PMC6798929, DOI: 10.1017/cts.2017.200.Peer-Reviewed Original ResearchTemporal lobe epilepsyDays of drinkingDentate hilusBCAA groupNeuronal viabilityControl groupHilar neuron lossHilar neuronal lossRight dentate gyrusRelevant rodent modelsRole of BCAABCAA ingestionNeuronal lossSpontaneous seizuresLobe epilepsyNeuron lossSeizure activityChronic ingestionDentate gyrusInfusion siteHilar regionRodent modelsMethionine sulfoximineNeurochemical modulationRats