2018
A Biocontainment Procedure for Intravital Microscopy of High-Risk Pathogens
Haugh K, Pi R, Fontes B, Mothes W, Uchil P. A Biocontainment Procedure for Intravital Microscopy of High-Risk Pathogens. Applied Biosafety 2018, 23: 211-222. DOI: 10.1177/1535676018785177.Peer-Reviewed Original ResearchStudy of HIVStandard operating proceduresIntravital microscopy studiesIntravital multiphoton microscopyHigh-risk pathogensHigh-risk studiesRisk group 2Intravital imaging techniquesGroup 2Intravital microscopyIntravital imagingImaging techniquesPathogen-host interactionsPathogensMultiphoton microscopyComplex techniquesHIV
2015
HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy
Agosto LM, Uchil PD, Mothes W. HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy. Trends In Microbiology 2015, 23: 289-295. PMID: 25766144, PMCID: PMC4417442, DOI: 10.1016/j.tim.2015.02.003.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyVirological synapsesT-cell depletionCell transmissionHIV infectionCell depletionHIV cellMatter of debateViral replicationTherapyUninfected cellsReduced efficacyHigh MOISynapsesHIVPathogenesisRecent dataInfectionCell deathTrigger cell deathCellsVivoCell-cell contactCellular surveillanceHigher number