Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy
Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes & Control 2011, 23: 355-361. PMID: 22187142, DOI: 10.1007/s10552-011-9884-7.Peer-Reviewed Original ResearchConceptsACF countRepeat colonoscopyColorectal neoplasiaFamily historyPrevious adenomaSurveillance colonoscopyColorectal cancerClinical surveillance guidelinesFuture advanced neoplasiaAdvanced colorectal neoplasiaAberrant crypt fociSections of colonACF frequencyConclusionsIncreased numberDistal colorectumPrior adenomasBaseline examinationSmoking historyAdvanced neoplasiaACF numberSub analysisSurveillance guidelinesSurveillance examsCrypt fociMAIN OUTCOMERisk Factors for Sessile Serrated Adenomas
Anderson JC, Rangasamy P, Rustagi T, Myers M, Sanders M, Vaziri H, Wu G, Birk JW, Protiva P. Risk Factors for Sessile Serrated Adenomas. Journal Of Clinical Gastroenterology 2011, 45: 694-699. PMID: 21325950, DOI: 10.1097/mcg.0b013e318207f3cf.Peer-Reviewed Original ResearchConceptsColorectal cancerTubular adenomaDiabetes mellitusRisk factorsPack-year exposureUse of aspirinSessile serrated adenomasCRC screeningFamily historyPatientsSerrated adenomasAdenomasMultivariate analysisMolecular abnormalitiesSmokersMellitusSmokingLesionsGroupNonsmokersSet of controlsStatinsObesityAspirinImportant pathwayChemoprevention
Singerman J, Protiva P. Chemoprevention. Clinical Gastroenterology 2011, 187-200. DOI: 10.1007/978-1-60761-398-5_12.Peer-Reviewed Original ResearchColorectal cancerCancer-related death rateColorectal cancer riskCommon malignancyLynch syndromeCancer preventionFamily historyCancer killerCancer riskNutritional statusNew casesCancerDeath rateEnvironmental exposuresPharmaceutical agentsHeritable disorderRiskUnited StatesMost casesChemoprophylaxisChemopreventionHNPCCMalignancySyndromeAgents