2024
A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes
Zhang L, Wang D, Shi P, Li J, Niu J, Chen J, Wang G, Wu L, Chen L, Yang Z, Li S, Meng J, Ruan F, He Y, Zhao H, Ren Z, Wang Y, Liu Y, Shi X, Wang Y, Liu Q, Li J, Wang P, Wang J, Zhu Y, Cheng G. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. Science 2024, 384: eadn9524. PMID: 38669573, DOI: 10.1126/science.adn9524.Peer-Reviewed Original ResearchMeSH KeywordsAcetobacteraceaeAedesAnimalsDengueDengue VirusFemaleFlavivirusGastrointestinal MicrobiomeMosquito VectorsSymbiosisViral Envelope ProteinsZika VirusZika Virus InfectionConceptsColony forming unitsFlavivirus envelope proteinCommensal microbiotaIrreversible conformational changesGlucose dehydrogenaseMosquito gutConformational changesGut lumenPrevent viral infectionGutBacteriumFlavivirus transmissionEnvelope proteinsVector competencePrevent viral entryViral entryRefractory to infectionDengue virusForming unitsField mosquitoesTransmission of dengue virusFlavivirusesMosquitoesSemifield conditionsAdult mosquitoes
2018
A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses
Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host & Microbe 2018, 25: 101-112.e5. PMID: 30595552, DOI: 10.1016/j.chom.2018.11.004.Peer-Reviewed Original ResearchConceptsArboviral infectionsCommensal bacteriumGut bacteriaDengue virus infectionGut commensal bacteriumCultivable gut bacteriaAedes aegypti mosquitoesVirus infectionViral disseminationAntibiotic depletionIntestinal tractOral introductionGut microbiomeGut epitheliumInfectionMembrane-bound mucinsHuman virusesAegypti mosquitoesHematophagous vectorsVector competenceArbovirusesField mosquitoesSerratia marcescensMosquitoesVirus
2017
A Mesh–Duox pathway regulates homeostasis in the insect gut
Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh–Duox pathway regulates homeostasis in the insect gut. Nature Microbiology 2017, 2: 17020. PMID: 28248301, PMCID: PMC5332881, DOI: 10.1038/nmicrobiol.2017.20.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsDrosophila melanogasterDual OxidasesGastrointestinal MicrobiomeGastrointestinal TractHomeostasisMembrane ProteinsSignal TransductionConceptsInsect gutERK phosphorylation cascadeCentral homeostatic mechanismDrosophila melanogasterMetazoan gutComplex communitiesPhosphorylation cascadeBacterial microbiomeDual oxidaseDuox expressionGut bacteriaGut bacterial microbiomeBlood mealHomeostasisBacterial microorganismsAedes aegyptiPathwayHomeostatic mechanismsMicroorganismsPhysiological changesGutExpressionMelanogasterImportant roleDynamic changes