2015
The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis
Malik J, Getman M, Lillis J, Gallagher P, Steiner L. The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis. Blood 2015, 126: 3577. DOI: 10.1182/blood.v126.23.3577.3577.Peer-Reviewed Original ResearchCell cycle progressionNuclear condensationTranscriptional regulationMammalian erythropoiesisErythroid maturationGATA2 expressionErythroid cellsCycle progressionHistone H4 lysine 20Sole histone methyltransferaseGFP fusion proteinH4 lysine 20Histone methyltransferase Setd8Erythroid transcription factorsErythroid-specific genesEarly embryonic lethalityGlobal transcriptome analysisDNA damage responseMajority of transcriptsRNA-seq analysisCell cycle checkpointsKey regulatory regionsCommitted erythroid progenitorsErythro-myeloid progenitorsPrimary human erythroblasts
2011
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation
Pilon AM, Ajay SS, Kumar SA, Steiner LA, Cherukuri PF, Wincovitch S, Anderson SM, Mullikin J, Gallagher P, Hardison R, Margulies E, Bodine D. Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood 2011, 118: e139-e148. PMID: 21900194, PMCID: PMC3208289, DOI: 10.1182/blood-2011-05-355107.Peer-Reviewed Original ResearchConceptsErythroid Kruppel-like factorKruppel-like factorChIP-seqTranscription factorsGenome-wide ChIP-seqProgenitor cellsMouse erythroid progenitor cellsCell cycle regulatory pathwaysErythroid transcription factorsGeneral cell growthRNA-seq analysisErythroid progenitor cellsTranscriptional activatorGATA factorsIntragenic regionsErythrocyte differentiationRegulatory pathwaysNuclear distributionPromoter regionParallel sequencingInteractomeDifferentiated erythroblastsCell growthTAL1Little overlap