2016
Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction
Gandhi PU, Chow SL, Rector TS, Krum H, Gaggin HK, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Carson PE, Januzzi JL, Anand IS. Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction. Journal Of Cardiac Failure 2016, 23: 20-28. PMID: 27317843, DOI: 10.1016/j.cardfail.2016.06.006.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-binding protein 7Heart failureCause mortalityPrimary outcomeEjection fractionHF eventsInsulin-like growth factorEjection Fraction trialGlomerular filtration rateSigns/symptomsProtein 7Binding protein 7Cardiovascular eventsMultivariable adjustmentSecondary outcomesCardiovascular hospitalizationPrognostic valueFiltration ratePrognostic meritTreatment groupsGrowth factorOutcomesFurther studiesPatientsEGFR
2015
Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome
Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK, Januzzi JL. Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome. Circulation Cardiovascular Quality And Outcomes 2015, 9: 55-63. PMID: 26646818, PMCID: PMC4720551, DOI: 10.1161/circoutcomes.115.002184.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePhysical activityBaseline optimismCardiac readmissionACS patientsCoronary syndromeMultivariable Cox regressionSubsequent physical activityGreater physical activityMultivariable linear regressionBeneficial health outcomesPositive psychological constructsCardiac rehospitalizationCardiovascular outcomesMedical comorbiditiesClinical outcomesCox regressionACS outcomesPrognostic biomarkerHealth outcomesBaseline activityPsychological covariatesReadmissionBiomarkersEffects of optimism
2014
Clinical Impact of Atrial Fibrillation in Patients With the HeartMate II Left Ventricular Assist Device
Enriquez AD, Calenda B, Gandhi PU, Nair AP, Anyanwu AC, Pinney SP. Clinical Impact of Atrial Fibrillation in Patients With the HeartMate II Left Ventricular Assist Device. Journal Of The American College Of Cardiology 2014, 64: 1883-1890. PMID: 25444141, DOI: 10.1016/j.jacc.2014.07.989.Peer-Reviewed Original ResearchConceptsParoxysmal atrial fibrillationAtrial fibrillationHF hospitalizationThromboembolic eventsVentricular assist deviceHeartMate IIHMII LVADAssist deviceImpact of AFCox proportional hazards regressionEffect of AFKaplan-Meier survival analysisHigh INR levelsHeart failure hospitalizationMajor bleeding eventsPersistent atrial fibrillationProportional hazards regressionBleeding eventsHMII implantationINR levelsFailure hospitalizationPatient yearsComposite endpointIndependent predictorsClinical outcomesPrognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function?
Gandhi PU, Gaggin HK, Sheftel AD, Belcher AM, Weiner RB, Baggish AL, Motiwala SR, Liu PP, Januzzi JL. Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function? The American Journal Of Cardiology 2014, 114: 1543-1549. PMID: 25248814, DOI: 10.1016/j.amjcard.2014.08.018.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDisease ProgressionEchocardiography, DopplerFemaleFollow-Up StudiesHeart Failure, DiastolicHumansInsulin-Like Growth Factor Binding ProteinsMaleMiddle AgedMyocardial ContractionPrognosisProspective StudiesSeverity of Illness IndexStroke VolumeTime FactorsVentricular Function, LeftConceptsInsulin-like growth factor-binding protein 7Right ventricular systolic pressureReduced ejection fractionAtrial volume indexVentricular systolic pressureTransmitral E/Diastolic functionIGFBP7 concentrationsHeart failureEjection fractionSystolic pressureVolume indexEchocardiographic parametersHigher left atrial volume indexLeft atrial volume indexInsulin-like growth factorAmbulatory heart failureAbnormal diastolic functionMyocardial diastolic functionNovel prognostic biomarkerProtein 7Binding protein 7Echocardiographic abnormalitiesFinal echocardiogramCardiovascular events