2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2018
Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women
Wenner MM, Hinds KA, Howard JT, Nawn CD, Stachenfeld NS, Convertino VA. Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women. Journal Of Trauma And Acute Care Surgery 2018, 85: s77-s83. PMID: 29443858, PMCID: PMC6023758, DOI: 10.1097/ta.0000000000001837.Peer-Reviewed Original ResearchConceptsLower body negative pressureBeat blood pressureHg lower body negative pressureCentral blood volumeCompensatory reserve measurementHeart rateWhite womenBlood volumeProgressive lower body negative pressureInadequate tissue oxygenationSigns/symptomsBody negative pressureProgressive central hypovolemiaRacial differencesStandard vital signsAfrican American womenBlood pressureHemodynamic decompensationAA womenCentral hypovolemiaRetrospective analysisTissue oxygenationRate of declineHemorrhageNegative pressure
2014
Impact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers
Alian AA, Galante NJ, Stachenfeld NS, Silverman DG, Shelley KH. Impact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers. Physiological Measurement 2014, 35: 1509-1520. PMID: 24901895, DOI: 10.1088/0967-3334/35/7/1509.Peer-Reviewed Original ResearchConceptsLower body negative pressureBlood pressureBody negative pressureCardiac modulationHeart ratePulse pressurePVP waveformsProgressive lower body negative pressureArterial systolic blood pressureFinger arterial blood pressurePeripheral venous pressure waveformsMmHg lower body negative pressureMean blood pressureDiastolic blood pressureSystolic blood pressureArterial blood pressureArterial BP valuesPressure waveformSignificant reductionMild hypovolemiaVenous pressureHemodynamic changesIntravenous siteRespiratory modulationBP values
2013
Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2012
Autonomic control mechanism of maximal lower body negative pressure application
Selvaraj N, Shelley K, Silverman D, Stachenfeld N, Chon K. Autonomic control mechanism of maximal lower body negative pressure application. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3120-3123. PMID: 23366586, DOI: 10.1109/embc.2012.6346625.Peer-Reviewed Original ResearchConceptsLower body negative pressureDiastolic blood pressureHeart rate variabilityBlood pressure variabilityAutonomic control mechanismsPulse pressureSevere hemorrhageTermination of LBNPLower body negative pressure applicationMaximal lower body negative pressureSystolic blood pressure variabilityRoot mean square successive differenceBody negative pressureConscious human subjectsNegative pressure applicationMean square successive differenceSquare successive differenceHigh-frequency powerLBNP applicationSympathetic reflexesAutonomic reflexesSympathetic activityBaroreflex sensitivityBlood pressureLBNP toleranceThe Effects of Undergarment Composition Worn Beneath Hockey Protective Equipment on High-Intensity Intermittent Exercise
Noonan B, Stachenfeld N. The Effects of Undergarment Composition Worn Beneath Hockey Protective Equipment on High-Intensity Intermittent Exercise. The Journal Of Strength And Conditioning Research 2012, 26: 2309-2316. PMID: 22706578, DOI: 10.1519/jsc.0b013e3182606e1e.Peer-Reviewed Original Research
2010
Greater Orthostatic Tolerance in Young Black Compared With White Women
Hinds K, Stachenfeld NS. Greater Orthostatic Tolerance in Young Black Compared With White Women. Hypertension 2010, 56: 75-81. PMID: 20458005, PMCID: PMC2909588, DOI: 10.1161/hypertensionaha.110.150011.Peer-Reviewed Original ResearchConceptsLower body negative pressureBody negative pressureOrthostatic toleranceWhite womenHeart rateGreater sympathetic nervous system responseR intervalSympathetic nervous system responsesPlasma renin activityPlasma catecholamine concentrationsSerum aldosterone concentrationNervous system responsesNegative pressureBlack womenCumulative stress indexWoman underwentRenin activityAldosterone concentrationBaroreflex functionBlood pressureCatecholamine concentrationsOrthostatic challengePlasma concentrationsHealthy blacksBlood samples
1995
Effects of blood donation on exercise performance in competitive cyclists
Panebianco R, Stachenfeld N, Coplan N, Gleim G. Effects of blood donation on exercise performance in competitive cyclists. American Heart Journal 1995, 130: 838-840. PMID: 7572594, DOI: 10.1016/0002-8703(95)90085-3.Peer-Reviewed Original Research
1994
Comparison of submaximal treadmill and supine bicycle exercise
Coplan N, Sacknoff D, Stachenfeld N, Gleim G. Comparison of submaximal treadmill and supine bicycle exercise. American Heart Journal 1994, 128: 416-418. PMID: 8037113, DOI: 10.1016/0002-8703(94)90499-5.Peer-Reviewed Original ResearchEffect of athletic training on heart rate variability
Sacknoff D, Gleim G, Stachenfeld N, Coplan N. Effect of athletic training on heart rate variability. American Heart Journal 1994, 127: 1275-1278. PMID: 8172056, DOI: 10.1016/0002-8703(94)90046-9.Peer-Reviewed Original ResearchConceptsHeart rate variabilityRate variabilityParasympathetic toneControl subjectsHeart diseaseVagal activityBaseline parasympathetic toneCardiac vagal toneFrequency domain variablesChronic exerciseHabitual exercisePrognostic stratificationVagal toneControl groupEndurance athletesActivity levelsPatientsAthletic trainingAthletesDiseaseToneExerciseAccurate indicatorSubjectsPrognosis
1992
Predictive accuracy of criteria used to assess maximal oxygen consumption
Stachenfeld N, Eskenazi M, Gleim G, Coplan N, Nicholas J. Predictive accuracy of criteria used to assess maximal oxygen consumption. American Heart Journal 1992, 123: 922-925. PMID: 1550001, DOI: 10.1016/0002-8703(92)90697-t.Peer-Reviewed Original ResearchConceptsAge-predicted maximal heart rateMaximal heart rateHeart rateMaximal testProgressive testIncremental cycle ergometryMaximal work rateRespiratory exchange ratioNegative predictive valueMaximal oxygen consumptionOxygen consumptionExercise testPeak lactateCycle ergometryPredictive valueSeparate daysExchange ratioThird dayWork rateInsensitive measureVO2 plateauSensitive criteriaSubjectsDaysPredictive accuracy
1991
Evaluation of 85% predicted maximal heart rate as an end point for diagnostic exercise testing
Coplan N, Gleim G, Stachenfeld N, Eskenazi M, Morales M, Nicholas J. Evaluation of 85% predicted maximal heart rate as an end point for diagnostic exercise testing. American Heart Journal 1991, 122: 1790-1791. PMID: 1957782, DOI: 10.1016/0002-8703(91)90307-4.Peer-Reviewed Original ResearchGender differences in the systolic blood pressure response to exercise
Gleim G, Stachenfeld N, Coplan N, Nicholas J. Gender differences in the systolic blood pressure response to exercise. American Heart Journal 1991, 121: 524-530. PMID: 1990758, DOI: 10.1016/0002-8703(91)90721-s.Peer-Reviewed Original ResearchConceptsSystolic blood pressure responseBlood pressure responseSystolic blood pressureBody surface areaLean body massBlood pressurePressure responseBody weightHigher systolic blood pressureSympathetic nervous system responsesNormal cardiac responseUrinary norepinephrine excretionPeak heart rateNervous system responsesGender differencesNorepinephrine excretionBody massExercise modalitiesDynamic exerciseHeart rateCardiac responseInfluence of genderMenModalitiesResponse