2012
Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end
Bai H, Kath J, Zörgiebel F, Sun M, Ghosh P, Hatfull G, Grindley N, Marko J. Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16546-16551. PMID: 23011800, PMCID: PMC3478594, DOI: 10.1073/pnas.1203118109.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDeoxyribonuclease IDNADNA Topoisomerases, Type IDNA, SuperhelicalEnzymesHumansKineticsModels, ChemicalMotionNucleic Acid ConformationSubstrate Specificity
2007
Conformational Changes during Normal and Error-Prone Incorporation of Nucleotides by a Y-Family DNA Polymerase Detected by 2-Aminopurine Fluorescence †
DeLucia A, Grindley N, Joyce C. Conformational Changes during Normal and Error-Prone Incorporation of Nucleotides by a Y-Family DNA Polymerase Detected by 2-Aminopurine Fluorescence †. Biochemistry 2007, 46: 10790-10803. PMID: 17725324, DOI: 10.1021/bi7006756.Peer-Reviewed Original Research2-AminopurineArchaeal ProteinsBase Pair MismatchBase SequenceDeoxyribonucleotidesDNA Polymerase betaDNA Polymerase IDNA RepairDNA ReplicationDNA-Directed DNA PolymeraseFluorescent DyesFrameshift MutationModels, MolecularMolecular Sequence DataMutagenesis, InsertionalNucleic Acid ConformationSpectrometry, FluorescenceSubstrate SpecificitySulfolobusTemplates, Genetic
2006
Mechanisms of Site-Specific Recombination*
Grindley ND, Whiteson KL, Rice PA. Mechanisms of Site-Specific Recombination*. Annual Review Of Biochemistry 2006, 75: 567-605. PMID: 16756503, DOI: 10.1146/annurev.biochem.73.011303.073908.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatalytic DomainDNADNA, CruciformIntegrasesModels, MolecularMolecular StructureNucleic Acid ConformationProtein ConformationRecombinasesRecombination, Genetic
2001
A Model for the γδ Resolvase Synaptic Complex
Sarkis G, Murley L, Leschziner A, Boocock M, Stark W, Grindley N. A Model for the γδ Resolvase Synaptic Complex. Molecular Cell 2001, 8: 623-631. PMID: 11583624, DOI: 10.1016/s1097-2765(01)00334-3.Peer-Reviewed Original Research
1997
Two abundant intramolecular transposition products, resulting from reactions initiated at a single end, suggest that IS2 transposes by an unconventional pathway
Lewis L, Grindley N. Two abundant intramolecular transposition products, resulting from reactions initiated at a single end, suggest that IS2 transposes by an unconventional pathway. Molecular Microbiology 1997, 25: 517-529. PMID: 9302014, DOI: 10.1046/j.1365-2958.1997.4871848.x.Peer-Reviewed Original ResearchBacterial ProteinsBase SequenceBinding SitesCloning, MolecularDNA NucleotidyltransferasesDNA PrimersDNA Transposable ElementsDNA, BacterialDNA, CircularEscherichia coliEscherichia coli ProteinsMicroscopy, ElectronModels, GeneticMolecular Sequence DataNucleic Acid ConformationPolymerase Chain ReactionRecombinant Fusion ProteinsTransposases
1991
Resolvase‐catalysed reactions between res sites differing in the central dinucleotide of subsite I.
Stark W, Grindley N, Hatfull G, Boocock M. Resolvase‐catalysed reactions between res sites differing in the central dinucleotide of subsite I. The EMBO Journal 1991, 10: 3541-3548. PMID: 1655422, PMCID: PMC453083, DOI: 10.1002/j.1460-2075.1991.tb04918.x.Peer-Reviewed Original Research
1988
The gamma delta resolvase bends the res site into a recombinogenic complex.
Salvo J, Grindley N. The gamma delta resolvase bends the res site into a recombinogenic complex. The EMBO Journal 1988, 7: 3609-3616. PMID: 2850169, PMCID: PMC454865, DOI: 10.1002/j.1460-2075.1988.tb03239.x.Peer-Reviewed Original Research
1987
Helical phasing between DNA bends and the determination of bend direction
Salvo J, Grindley N. Helical phasing between DNA bends and the determination of bend direction. Nucleic Acids Research 1987, 15: 9771-9779. PMID: 2827112, PMCID: PMC306530, DOI: 10.1093/nar/15.23.9771.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceElectrophoresis, Polyacrylamide GelLeishmaniaModels, GeneticNucleic Acid ConformationNucleotidyltransferasesPlasmidsTransposasesThe γδ resolvase induces an unusual DNA structure at the recombinational crossover point
Hatfull G, Noble S, Grindley N. The γδ resolvase induces an unusual DNA structure at the recombinational crossover point. Cell 1987, 49: 103-110. PMID: 3030563, DOI: 10.1016/0092-8674(87)90760-4.Peer-Reviewed Original Research
1984
Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically.
Abdel-Meguid S, Grindley N, Templeton N, Steitz T. Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 2001-2005. PMID: 6326096, PMCID: PMC345424, DOI: 10.1073/pnas.81.7.2001.Peer-Reviewed Original Research