2012
Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end
Bai H, Kath J, Zörgiebel F, Sun M, Ghosh P, Hatfull G, Grindley N, Marko J. Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16546-16551. PMID: 23011800, PMCID: PMC3478594, DOI: 10.1073/pnas.1203118109.Peer-Reviewed Original Research
2011
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase
Bai H, Sun M, Ghosh P, Hatfull GF, Grindley ND, Marko JF. Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 7419-7424. PMID: 21502527, PMCID: PMC3088605, DOI: 10.1073/pnas.1018436108.Peer-Reviewed Original ResearchMeSH KeywordsBiotinDigoxigeninDNA NucleotidyltransferasesDNA, SuperhelicalEscherichia coliPlasmidsRotationSerine
1999
Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity
Arnold P, Blake D, Grindley N, Boocock M, Stark W. Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity. The EMBO Journal 1999, 18: 1407-1414. PMID: 10064606, PMCID: PMC1171230, DOI: 10.1093/emboj/18.5.1407.Peer-Reviewed Original Research
1981
Transposon-mediated site-specific recombination in vitro: DNA cleavage and protein-DNA linkage at the recombination site
Reed R, Grindley N. Transposon-mediated site-specific recombination in vitro: DNA cleavage and protein-DNA linkage at the recombination site. Cell 1981, 25: 721-728. PMID: 6269756, DOI: 10.1016/0092-8674(81)90179-3.Peer-Reviewed Original ResearchConceptsSite-specific recombinationTransposable element gamma deltaDNA cleavageTnpR genePalindromic sequence 5'Intercistronic regionSequence 5DNA moleculesResolution siteResolvaseSame substrate moleculeRecombination sitesAbsence of Mg2Substrate moleculesGenesSame repliconRecombinationDNACleavageTransposonRes sitesSites