Nicola Santoro, MD, PhD
Associate Professor of PediatricsDownloadHi-Res Photo
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Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States
About
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Titles
Associate Professor of Pediatrics
Biography
1993-1999 Student of Medicine at the Second University of Naples (Napoli – Italy)
1997-1999 Intern, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2000-2005 Resident, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2003 Visiting Scientist Human Genomics Lab directed by Dr Claude Bouchard at Pennington Biomedical Research Center (Louisiana State University), Baton Rouge, LA, USA.
2005-2008 PhD student of Pharmacology and Respiratory Pathophysiology, at the Second University of Napoli (Napoli, Italy)
2009-2010 Post doctoral research associate, Department of Pediatrics Yale University (New Haven, CT)
2011-2017 Associate Research Scientist, Department of Pediatrics, Yale University (New Haven, CT)
2017-2020 Assistant Professor, Department of Pediatrics, Yale University (New Haven, CT)
2020- Associate Professor, Department of Pediatrics, Yale University (New Haven, CT)
Last Updated on May 15, 2024.
Appointments
Pediatric Endocrinology & Diabetes
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Post doctoral research associate
- Yale University (2010)
- PhD
- Seconda Universita degli Studi di Napoli (2008)
- Residency
- Seconda Universita' degli Studi di Napoli (2005)
- MD
- Seconda Universita degli Studi di Napoli (1999)
Research
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Overview
Our lab focuses on clinical/translational research in pediatric obesity and its complications such as prediabetes and MASLD. We use state-of-the-art techniques such as MRI, MRS, euglycemic and hyperglycemic clamps, stable isotopes infusion, mathematical modeling to study human metabolism and complex diseases pathophysiology.
Medical Research Interests
Metabolic Diseases; Nutrition Disorders
Public Health Interests
Genetics, Genomics, Epigenetics; Metabolism; Nutrition; Obesity; Child/Adolescent Health
ORCID
0000-0001-6437-4173
Research at a Glance
Yale Co-Authors
Frequent collaborators of Nicola Santoro's published research.
Publications Timeline
A big-picture view of Nicola Santoro's research output by year.
Alfonso Galderisi, MD, PhD
Sonia Caprio, MD
Michelle Van Name, MD
Stephanie Samuels, MD
Daniel F Vatner, MD, PhD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
40Publications
974Citations
Publications
2026
Improved outcomes of the refined risk-stratification and risk-adapted therapy in children with acute myeloid leukemia: final results of the AIEOP AML 2013
Locatelli F, Buldini B, Pigazzi M, Rizzari C, Menna G, Fagioli F, Tumino M, Lo Nigro L, D’Angelo P, Cefalo M, Paganelli V, Strocchio L, Becilli M, Spinelli M, Giagnuolo G, Saglio F, Santoro N, Micalizzi C, Zecca M, Masetti R, Merli P. Improved outcomes of the refined risk-stratification and risk-adapted therapy in children with acute myeloid leukemia: final results of the AIEOP AML 2013. Journal Of Hematology & Oncology 2026, 19: 35. PMID: 42010655, PMCID: PMC13224531, DOI: 10.1186/s13045-026-01798-3.Peer-Reviewed Original ResearchCitationsCefiderocol in Children with Hematologic Malignancies—The Multicenter Retrospective Experience of the Infection Working Group of the Italian Pediatric Hematology and Oncology Association (AIEOP)
Muggeo P, Galaverna F, Chiusaroli L, Perruccio K, Coccia P, Baccelli F, Boccieri E, Rosignoli C, De Leonardis F, Santoro N, Cesaro S. Cefiderocol in Children with Hematologic Malignancies—The Multicenter Retrospective Experience of the Infection Working Group of the Italian Pediatric Hematology and Oncology Association (AIEOP). Journal Of Clinical Medicine 2026, 15: 3100. PMID: 42074901, PMCID: PMC13116458, DOI: 10.3390/jcm15083100.Peer-Reviewed Original Research
2025
Biomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity
Refugjati E, Li Z, Umano G, Galuppo B, Van Name M, Samuels S, Kang G, Barbieri E, Hwang J, Santoro N. Biomarkers of Glycolysis and the Tricarboxylic Acid Cycle in Youth with and without Obesity. Hormone Research In Paediatrics 2025, 1-6. PMID: 41411205, PMCID: PMC12749259, DOI: 10.1159/000548624.Peer-Reviewed Original ResearchAltmetricAltered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Strober J, Ter Horst K, Sung D, Jongejan A, Slusher A, Gassaway B, Tarabra E, Paulo J, Shuken S, Gygi S, Santoro N, Caprio S, Serlie M, Bogan J, Vatner D. Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue. Diabetes 2025, 75: 341-350. PMID: 41347935, PMCID: PMC12823340, DOI: 10.2337/db25-0488.Peer-Reviewed Original ResearchAltmetricPsychological and Psychosocial Effects of Cancer on Young Patients and Survivors in Italy: A Mixed-Methods Study on the Challenges and Meaning-Making Factors
Gentile M, Ronconi L, Romeo M, De Vincenzo C, Burattini E, Rutigliano C, Santoro N, Zucchetti G, Fagioli F, Testoni I. Psychological and Psychosocial Effects of Cancer on Young Patients and Survivors in Italy: A Mixed-Methods Study on the Challenges and Meaning-Making Factors. Diseases 2025, 13: 367. PMID: 41294907, PMCID: PMC12650988, DOI: 10.3390/diseases13110367.Peer-Reviewed Original ResearchCitationsA multicentric survey of the experience and perception of medical music therapy among health professionals in Italian AIEOP paediatric cancer centres
Giordano F, Trevor-Briscoe T, Rutigliano C, Muggeo P, Aledda O, Borgonovi L, Campanelli D, Capolsini L, Catapano L, Di Pasquale M, Ferrari D, Quaranta V, Mastrolorenzo A, Murittu P, Scaringella L, Zanchi B, Santoro N, Cesar S. A multicentric survey of the experience and perception of medical music therapy among health professionals in Italian AIEOP paediatric cancer centres. The Arts In Psychotherapy 2025, 95: 102331. DOI: 10.1016/j.aip.2025.102331.Peer-Reviewed Original ResearchCitationsBridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation
Carbone F, Després J, Ioannidis J, Neeland I, Garruti G, Busetto L, Liberale L, Ministrini S, Vilahur G, Schindler T, Macedo M, Di Ciaula A, Krawczyk M, Geier A, Baffy G, Faienza M, Farella I, Santoro N, Frühbeck G, Yárnoz‐Esquiroz P, Gómez‐Ambrosi J, Chávez‐Manzanera E, Vázquez‐Velázquez V, Oppert J, Kiortsis D, Sbraccia P, Zoccali C, Portincasa P, Montecucco F. Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation. European Journal Of Clinical Investigation 2025, 55: e70059. PMID: 40371883, PMCID: PMC12257286, DOI: 10.1111/eci.70059.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricBone Remodeling in Children with Acute Lymphoblastic Leukemia: A Two-Year Prospective Longitudinal Study
Muggeo P, Grassi M, D’Ascanio V, Forte J, Brescia V, Di Serio F, Piacente L, Giordano P, Santoro N, Faienza M. Bone Remodeling in Children with Acute Lymphoblastic Leukemia: A Two-Year Prospective Longitudinal Study. International Journal Of Molecular Sciences 2025, 26: 4307. PMID: 40362542, PMCID: PMC12072470, DOI: 10.3390/ijms26094307.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentBiomarkersBone RemodelingChildChild, PreschoolFemaleHumansIntercellular Signaling Peptides and ProteinsLongitudinal StudiesMaleOsteocalcinOsteoprotegerinPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRANK LigandTartrate-Resistant Acid PhosphataseATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.Peer-Reviewed Original ResearchCitationsAltmetricCefiderocol for severe bloodstream infection by multidrug-resistant Klebsiella pneumoniae in a pediatric patient with acute myeloid leukemia
De Leonardis F, Marasciulo F, Koronica R, Servedio M, Pentassuglia E, Miani V, Dalfino L, Stolfa S, Santoro N. Cefiderocol for severe bloodstream infection by multidrug-resistant Klebsiella pneumoniae in a pediatric patient with acute myeloid leukemia. Pediatric Hematology Oncology Journal 2025, 10: 57-58. DOI: 10.1016/j.phoj.2025.02.003.Commentaries, Editorials and LettersCitations
Clinical Trials
Current Trials
Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Youth with Obesity
IRB ID2000028731RolePrincipal InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsGenderBothAge12 years - 22 yearsStudy to investigate adipocyte cell and lipid turnover in obese adolescents
IRB ID1503015459RoleSub InvestigatorPrimary Completion Date05/01/2025Recruiting ParticipantsGenderBothAge12 years - 21 yearsPrevalence of Carbohydrate Intolerance in Lean and Obese Children
IRB ID9909011190RoleSub InvestigatorPrimary Completion Date09/30/2025Recruiting ParticipantsGenderBothAge8 years - 18 years
Academic Achievements & Community Involvement
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Honors
honor Young Investigator Travel Grant Award
06/17/2014National AwardAmerican Diabetes AssociationDetailsUnited Stateshonor Yale Center for Clinical Investigation Scholar
07/01/2012National AwardDetailsUnited Stateshonor Travel Grant
10/12/2010National AwardThe Obesity SocietyDetailsUnited Stateshonor President Poster Award
09/23/2008International AwardEuropean Society for Pediatric EndocrinologyDetailsTurkeyhonor Young Researcher Award
09/01/2000International AwardSecond University of NapoliDetailsItaly
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Academic Office Number
Mailing Address
Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States