2021
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
Muthuraman M, Palotai M, Jávor-Duray B, Kelemen A, Koirala N, Halász L, Erőss L, Fekete G, Bognár L, Deuschl G, Tamás G. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage Clinical 2021, 32: 102857. PMID: 34662779, PMCID: PMC8526781, DOI: 10.1016/j.nicl.2021.102857.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesDeep Brain StimulationHumansHypokinesiaParkinson DiseaseSubthalamic NucleusConceptsSlope of changeContralateral stimulationPremotor cortexParkinson's diseasePrimary motorPresent cross-sectional studyBasal ganglia-thalamoBilateral subthalamic stimulationCross-sectional studyHigh beta frequency bandBeta frequency bandsParkinsonian patientsSubthalamic stimulationContralateral sideScreening periodSubthalamic nucleusBradykinesia severityCortical circuitsGamma frequency bandBradykinesiaDiseaseHigh-gamma frequency bandStimulation levelsStimulationCortex
2016
Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy
Alexandru H, Muthuraman M, Chirumamilla V, Koirala N, Paktas B, Deuschl G, Zeuner K, Groppa S. Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLOS ONE 2016, 11: e0168652. PMID: 27992533, PMCID: PMC5161386, DOI: 10.1371/journal.pone.0168652.Peer-Reviewed Original ResearchConceptsBenign essential blepharospasmHemifacial spasmBoNT therapyCortical thicknessBEB patientsHealthy controlsTemporal poleCommon hyperkinetic movement disordersStandard evidence-based treatmentGroup of patientsBotulinum neurotoxin therapyHyperkinetic movement disordersPrimary motor cortexDifferent pathophysiological mechanismsLower cortical thicknessEvidence-based treatmentsFacial musclesPre-supplementary motor areaRight superior frontal regionsGroup of ageLeft lingual gyrusSuperior frontal regionsGray matter integrityContrary patientsNeurotoxin therapy
2015
Testing the effects of pre-processing on voxel based morphometry analysis
Chaitanya C, Koirala N, Mideksa K, Anwar A, Schmidt G, Deuschl G, Groppa S, Muthuraman M. Testing the effects of pre-processing on voxel based morphometry analysis. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2015, 2015: 4302-4305. PMID: 26737246, DOI: 10.1109/embc.2015.7319346.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesGray MatterHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingConceptsGray matter volumeGray matter differencesDifferent time pointsTime pointsMagnetic resonance imagesBotulinum toxin injectionEvidence-based therapiesStructural grey matter differencesVoxel-wise comparisonBase therapyToxin injectionCross-sectional data analysisBotulinum toxinMatter volumeRespective musclesMorphometry analysisLongitudinal data analysisPatientsLongitudinal analysisResonance imagesInjectionBrainTreatmentSecond aimStatistical analysis