Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;
Koirala N, Fleischer V, Granert O, Deuschl G, Muthuraman M, Groppa S. Network Effects and Pathways in Deep Brain Stimulation in Parkinson's Disease**Koirala N, Fleischer V, Muthuraman M, Groppa S, are with the Johannes Gutenberg university hospital, 55131, Mainz and Granert O, Deuschl G is with University clinic Schleswig-Holstein, 24105, Kiel, Germany;. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2016, 2016: 5533-5536. PMID: 28269510, DOI: 10.1109/embc.2016.7591980.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDeep brain stimulationSTN-DBSParkinson's diseaseDiffusion tensor imagingBrain stimulationProbabilistic tractographyActive DBS contactsPostoperative clinical outcomesPrimary motor cortexStandard therapeutic optionIdiopathic Parkinson's diseaseCortico-spinal tractSubcortical seedsClinical outcomesTherapeutic optionsDBS contactsMotor cortexDBS treatmentUniversity HospitalSubthalamic nucleusMotor areaPremotor regionsStimulation siteTensor imagingIncreased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis
Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth S, Zipp F, Groppa S. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Multiple Sclerosis Journal 2016, 23: 432-441. PMID: 27246143, DOI: 10.1177/1352458516651503.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemMagnetic resonance imagingWhite matterClinical declineClinical impairmentRelapsing-remitting MS patientsEarly multiple sclerosisVoxel-based morphometryTemporo-parietal regionsNeuronal injuryConnectivity patternsMS patientsRemission phaseDisease stageDisease onsetHealthy controlsFunctional declineNervous systemGray matter networksResonance imagingProbabilistic tractographySclerosisStructural connectivityDisease