2020
Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation
Koirala N, Serrano L, Paschen S, Falk D, Anwar A, Kuravi P, Deuschl G, Groppa S, Muthuraman M. Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation. Scientific Reports 2020, 10: 19241. PMID: 33159098, PMCID: PMC7648837, DOI: 10.1038/s41598-020-74196-5.Peer-Reviewed Original ResearchConceptsMicroelectrode recordingsBackground activityStereotactic magnetic resonance imagingLow beta frequency rangeDeep brain stimulation surgeryBilateral STN-DBSSide effect ratioDeep brain stimulationBeta frequency rangeMagnetic resonance imagingSTN-DBSAwake patientsLead placementSubthalamic nucleusIntraoperative decisionAnatomical sitesBrain stimulationDBS electrodesOptimal target localizationResonance imagingMaximum spike rateBeta rangeSpike ratePatientsImplantationMyelination- and immune-mediated MR-based brain network correlates
Cerina M, Muthuraman M, Gallus M, Koirala N, Dik A, Wachsmuth L, Hundehege P, Schiffler P, Tenberge J, Fleischer V, Gonzalez-Escamilla G, Narayanan V, Krämer J, Faber C, Budde T, Groppa S, Meuth S. Myelination- and immune-mediated MR-based brain network correlates. Journal Of Neuroinflammation 2020, 17: 186. PMID: 32532336, PMCID: PMC7293122, DOI: 10.1186/s12974-020-01827-z.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCentral nervous systemCorpus callosumBrain network characteristicsCuprizone dietAnxiety-like behaviorFractional anisotropy valuesDiffusion tensor imagingBackgroundMultiple sclerosisConsistent demyelinationMyelin dynamicsKey anatomical regionsCuprizone modelMyelin lossNeuropsychiatric symptomsAutoimmune diseasesFunctional impairmentNeurodegenerative processesHistopathological basisCortical areasMRI metricsDemyelinationDisease processNervous systemFA reduction
2019
Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine
Michels L, Villanueva J, O’Gorman R, Muthuraman M, Koirala N, Büchler R, Gantenbein A, Sandor P, Luechinger R, Kollias S, Riederer F. Interictal Hyperperfusion in the Higher Visual Cortex in Patients With Episodic Migraine. Headache The Journal Of Head And Face Pain 2019, 59: 1808-1820. PMID: 31680242, DOI: 10.1111/head.13646.Peer-Reviewed Original ResearchConceptsCerebral blood flowCohen's d effect sizesEpisodic migraineD effect sizesHealthy controlsSuperior temporal gyrusASL-MRIVisual cortexInterictal cerebral blood flowInterictal stateTemporal gyrusHigher-order visual cortexNeuro-functional abnormalitiesEffect sizeFunctional brain imaging studiesNon-invasive imaging methodMagnetic resonance imagingHigher visual cortexBrain imaging studiesInterictal hyperperfusionCBF changesSubcortical alterationsMigraine pathophysiologyParietal operculumBlood flow
2017
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolution
2016
Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis
Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth S, Zipp F, Groppa S. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Multiple Sclerosis Journal 2016, 23: 432-441. PMID: 27246143, DOI: 10.1177/1352458516651503.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemMagnetic resonance imagingWhite matterClinical declineClinical impairmentRelapsing-remitting MS patientsEarly multiple sclerosisVoxel-based morphometryTemporo-parietal regionsNeuronal injuryConnectivity patternsMS patientsRemission phaseDisease stageDisease onsetHealthy controlsFunctional declineNervous systemGray matter networksResonance imagingProbabilistic tractographySclerosisStructural connectivityDisease