2019
Structural brain network fingerprints of focal dystonia
Chirumamilla V, Dresel C, Koirala N, Gonzalez-Escamilla G, Deuschl G, Zeuner K, Muthuraman M, Groppa S. Structural brain network fingerprints of focal dystonia. Therapeutic Advances In Neurological Disorders 2019, 12: 1756286419880664. PMID: 31798688, PMCID: PMC6859688, DOI: 10.1177/1756286419880664.Peer-Reviewed Original ResearchBSP patientsHFS patientsBoNT treatmentHealthy controlsFocal dystoniaHemifacial spasmSensorimotor cortexFrontal cortexTemporal cortexStructural magnetic resonance imagingReduced connectivityGray matter volumeDifferent brain regionsSymptomatic reductionMovement disordersStructural brain networksGraph-based network analysisPatientsMatter volumeBlepharospasmDystoniaParietal cortexResonance imagingBrain regionsDecreased connectivity
2017
Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies
Chiosa V, Groppa S, Ciolac D, Koirala N, Mişina L, Winter Y, Moldovanu M, Muthuraman M, Groppa S. Breakdown of Thalamo-Cortical Connectivity Precedes Spike Generation in Focal Epilepsies. Brain Connectivity 2017, 7: 309-320. PMID: 28494616, DOI: 10.1089/brain.2017.0487.Peer-Reviewed Original ResearchConceptsFrontal lobeVentral anterior nucleusThalamo-cortical connectivityFuture therapeutic approachesSpike generationFocal epileptic seizuresMedial dorsalThalamic volumeFocal epilepsyAnterior nucleusFrontal cortexTherapeutic approachesEpileptic seizuresCerebral networksCortical integrityThalamusEEG recordingsWidespread areasDistinct patternsLobeEpileptogenesisPatientsEpilepsySeizuresCortexEffects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation