2018
Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease
Muthuraman M, Koirala N, Ciolac D, Pintea B, Glaser M, Groppa S, Tamás G, Groppa S. Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease. Frontiers In Neurology 2018, 9: 711. PMID: 30210436, PMCID: PMC6119713, DOI: 10.3389/fneur.2018.00711.Peer-Reviewed Original ResearchDeep brain stimulationL-dopa therapyParkinson's diseaseBrain stimulationEffects of DBSL-DOPAImpact of DBSNon-motor symptomsEffective treatment optionEvidence-based therapiesEffective pharmacological therapyCentral nervous systemBrain networksPerioperative algorithmSpecific brain networksDopaminergic medicationPharmacological therapyClinical effectsMotor symptomsPD patientsPharmacodynamic effectsPharmacological treatmentTherapy optionsTreatment optionsFirst complication
2017
Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
Muthuraman M, Deuschl G, Koirala N, Riedel C, Volkmann J, Groppa S. Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex. Scientific Reports 2017, 7: 43571. PMID: 28262813, PMCID: PMC5337928, DOI: 10.1038/srep43571.Peer-Reviewed Original ResearchConceptsSTN-DBSParkinson's diseaseCortical thickness measurementsGray matter integrityClinical responseCortical atrophyMotor outcomePoor motor outcomeOptimal clinical responseIdiopathic Parkinson's diseaseDeep brain stimulationEffects of DBSGray matter propertiesClinical motor outcomePreoperative conditionClinical improvementClinical outcomesParkinsonian patientsPD patientsStandard treatmentDBS treatmentSubthalamic nucleusFrontal cortexCortical thicknessBrain stimulation