2020
Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2019
Gray matter integrity predicts white matter network reorganization in multiple sclerosis
Radetz A, Koirala N, Krämer J, Johnen A, Fleischer V, Gonzalez‐Escamilla G, Cerina M, Muthuraman M, Meuth S, Groppa S. Gray matter integrity predicts white matter network reorganization in multiple sclerosis. Human Brain Mapping 2019, 41: 917-927. PMID: 32026599, PMCID: PMC7268008, DOI: 10.1002/hbm.24849.Peer-Reviewed Original ResearchConceptsDeep gray matter volumesGray matter volumeMultiple sclerosisGray matter integrityMatter volumeWhite matter networksEarly relapsing-remitting multiple sclerosisRelapsing-remitting multiple sclerosisTime pointsGray matter atrophyDeep gray matter structuresCognitive performanceMiddle temporal cortexGray matter structuresGray matter regionsDisability progressionBrain stemMatter damageSignificant atrophyMatter atrophyDeep gray matter regionsCortical thicknessTemporal cortexTissue damageAtrophy