2019
Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis
Fleischer V, Koirala N, Droby A, Gracien R, Deichmann R, Ziemann U, Meuth S, Muthuraman M, Zipp F, Groppa S. Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis. Therapeutic Advances In Neurological Disorders 2019, 12: 1756286419838673. PMID: 31040880, PMCID: PMC6482642, DOI: 10.1177/1756286419838673.Peer-Reviewed Original ResearchRelapsing-remitting MSEarly relapsing-remitting MSHealthy controlsDisease activityEarly relapsing-remitting multiple sclerosisLongitudinal brain volume changesRelapsing-remitting multiple sclerosisCortical atrophy patternsStructural cortical networksPatients' disease activityNetwork reorganizationBrain volume changesClinical disease manifestationsDetectable atrophyMultiple sclerosisAtrophy patternsDisease manifestationsAtrophy measurementsCortical responsesGray matter networksBrain functionPatientsT MRICortical networksGraph theoretical analysis
2017
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth S, Groppa S. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Multiple Sclerosis Journal 2017, 25: 338-343. PMID: 29226779, DOI: 10.1177/1352458517748474.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCortical atrophyRelapsing-remitting multiple sclerosisBlood-brain barrier integrityLongitudinal magnetic resonance imagingCerebrospinal fluid markersGray matter pathologyHigher functional disabilityCerebrospinal fluid albuminQuotient of albuminMagnetic resonance imagingCumulative disabilityClinical disabilityWidespread atrophyFunctional disabilityCSF concentrationsCSF markersDisease progressionFunctional deteriorationImmunoglobulin AAtrophy measurementsFluid markersUnequivocal predictorsBarrier integrityDisease evolution