2024
Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Ivins-O’Keefe K, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V, investigators T. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study. Journal Of Clinical Neuroscience 2024, 126: 338-347. PMID: 39029302, DOI: 10.1016/j.jocn.2024.07.003.Peer-Reviewed Original ResearchConceptsC-reactive proteinNeuron-specific enolaseGlial fibrillary acidic proteinBiomarker levelsUbiquitin C-terminal hydrolase-L1Traumatic brain injuryDexmedetomidine exposureInjury biomarkersSevere traumatic brain injuryTRACK-TBIS100 calcium-binding protein BInflammatory biomarkers C-reactive proteinCalcium-binding protein BHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyCritically ill TBI patientsAlpha-2 agonistsBrain injuryBrain injury biomarkersBiomarkers C-reactive proteinModulate autonomic functionGlasgow Coma Scale score 3No significant associationSecondary brain injuryUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patientsContemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemia
2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2021
A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
Martini RP, Siler D, Cetas J, Alkayed NJ, Allen E, Treggiari MM. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2021, 36: 905-915. PMID: 34873674, DOI: 10.1007/s12028-021-01398-8.Peer-Reviewed Original ResearchConceptsSoluble epoxide hydrolaseAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageDHET ratiosEnd pointDay 7Day 10Primary study end pointSoluble epoxide hydrolase inhibitionCSF inflammatory cytokinesEET/DHET ratiosIncidence of DCIPrevention of DCITertiary end pointSecondary end pointsStudy end pointCerebral blood flowLength of stayEndothelial injury biomarkersEpoxide hydrolase inhibitionNeurovascular inflammationResultsTen patientsStudy drugAdverse eventsCytokine levelsAdherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample
Bardia A, Treggiari MM, Michel G, Dai F, Tickoo M, Wai M, Schuster K, Mathis M, Shah N, Kheterpal S, Schonberger RB. Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample. JAMA Network Open 2021, 4: e2137296. PMID: 34905007, PMCID: PMC8672234, DOI: 10.1001/jamanetworkopen.2021.37296.Peer-Reviewed Original ResearchConceptsSurgical site infectionAntibiotic prophylaxis guidelinesWeight-adjusted dosingInfectious Diseases SocietyAntibiotic choiceProphylaxis guidelinesCohort studyDiseases SocietyOverall adherenceFuture quality improvement effortsStudy periodAntibiotic administration guidelinesPrimary end pointTiming of administrationGynecological surgical proceduresQuality improvement effortsIntraoperative antibioticsOverall nonadherenceNoncardiac surgeryAdult patientsEmergency surgeryFirst doseGuideline adherenceSurgical encountersAmerica guidelinesTreatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatientsEarly but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaSevere COVID-19Convalescent plasmaPlasma recipientsHospital mortalityUnexposed cohortCCP administrationSevere COVID-19 infectionPropensity score-matched analysisCOVID-19Limited therapeutic optionsCOVID-19 infectionCoronavirus disease 2019CCP recipientsHospital stayPrimary endpointSecondary endpointsHospital daysHospital dischargeEarly administrationComplete followMechanical ventilationTherapeutic optionsClinical differencesSevere diseaseThe Role of Anesthesiologists in Perioperative Limitation of Potentially Life-Sustaining Medical Treatments: A Narrative Review and Perspective
Cushman T, Waisel DB, Treggiari MM. The Role of Anesthesiologists in Perioperative Limitation of Potentially Life-Sustaining Medical Treatments: A Narrative Review and Perspective. Anesthesia & Analgesia 2021, 133: 663-675. PMID: 34014183, DOI: 10.1213/ane.0000000000005559.Peer-Reviewed Original ResearchConceptsLife-sustaining medical treatmentPerioperative careMedical treatmentPerioperative Registered NursesImmediate perioperative periodGoals of careGoal-concordant careDaily clinical practiceRole of anesthesiologistsPrimary care colleaguesPerioperative periodElective surgeryGeneral anesthesiaCare discussionsResuscitate ordersPatient's wishesAmerican CollegeClinical practiceRegistered NursesNarrative reviewPhysiologic homeostasisAnesthesiologistsCareAmerican SocietyPatient autonomyAssisted Fluid Management Software Guidance for Intraoperative Fluid Administration
Maheshwari K, Malhotra G, Bao X, Lahsaei P, Hand WR, Fleming NW, Ramsingh D, Treggiari MM, Sessler DI, Miller TE. Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration. Anesthesiology 2021, 135: 273-283. PMID: 33901281, DOI: 10.1097/aln.0000000000003790.Peer-Reviewed Original ResearchConceptsFluid administrationFluid bolusStroke volumeNoncardiac surgeryHigh-risk noncardiac surgeryGoal-directed managementInadequate fluid administrationIntraoperative fluid administrationArterial catheter insertionIntravenous fluid administrationIntraoperative fluid managementCatheter insertionCohort evaluationMechanical ventilationFluid responsivenessFluid managementSD increaseFluid strategySurgeryBolusCliniciansAdministrationSV increaseExploratory basisMulticenterAnesthesia for Acute Spinal Cord Injury
Rao S, Treggiari MM. Anesthesia for Acute Spinal Cord Injury. Anesthesiology Clinics 2021, 39: 127-138. PMID: 33563376, DOI: 10.1016/j.anclin.2020.11.011.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injurySpinal cordSpinal cord perfusion pressureImportant anesthetic implicationsAcute hemodynamic changesLong-term morbidityLoss of bowelLevel of injuryFirst lumbar vertebraVentilator dependenceAirway stabilizationCord compressionSurgical emergencyBladder functionRespiratory musclesAnesthetic implicationsHemodynamic changesPerfusion pressureCauda equinaFluid managementInjuryLumbar vertebraeMorbidityBasics of Neuromonitoring and Anesthetic Considerations
Rao S, Kurfess J, Treggiari MM. Basics of Neuromonitoring and Anesthetic Considerations. Anesthesiology Clinics 2021, 39: 195-209. PMID: 33563382, DOI: 10.1016/j.anclin.2020.11.009.Peer-Reviewed Original ResearchComplementary and Alternative Medicine Services at Pain Treatment Clinics: A National Survey of Pain Medicine Specialists in the United States
Carson JW, Treggiari MM, Mauer KM, Kirsch JR. Complementary and Alternative Medicine Services at Pain Treatment Clinics: A National Survey of Pain Medicine Specialists in the United States. Journal Of Alternative And Complementary Medicine 2021, 27: 349-351. PMID: 33544018, DOI: 10.1089/acm.2020.0487.Peer-Reviewed Original Research
2020
COVID-19 mortality risk for older men and women
Yanez ND, Weiss NS, Romand JA, Treggiari MM. COVID-19 mortality risk for older men and women. BMC Public Health 2020, 20: 1742. PMID: 33213391, PMCID: PMC7675386, DOI: 10.1186/s12889-020-09826-8.Peer-Reviewed Original ResearchConceptsIncident rate ratiosCOVID-19 mortalityCOVID-19 mortality ratesMortality rateCOVID-19 deathsCOVID-19COVID-19 mortality riskPoisson mixed effects regression modelsHigh COVID-19 mortality ratesAge-specific ratesMixed effects regression modelsCOVID-19 casesAge 54Mortality riskHigh riskOlder menConsecutive weeksAge 65Age groupsSix-week periodYoung individualsRate ratioDeathEffects regression modelsWomenAgreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults.
Tiwary N, Treggiari MM, Yanez ND, Kirsch JR, Tekkali P, Taylor CC, Schenning KJ. Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults. Anesthesia & Analgesia 2020, 132: 1112-1119. PMID: 33002933, DOI: 10.1213/ane.0000000000005197.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia Recovery PeriodAnesthesia, GeneralCognitionCognitive DysfunctionElective Surgical ProceduresEmergence DeliriumFemaleHumansMaleMental Status and Dementia TestsPredictive Value of TestsPreoperative CareReproducibility of ResultsRisk AssessmentRisk FactorsTreatment OutcomeConceptsPostanesthesia care unitMini-Cog scorePACU deliriumDay of surgeryTimes higher oddsNormal cognitive functionCohort studyCognitive impairmentMini-CogPostoperative deliriumCognitive functionPreoperative clinicHigher oddsPatients meeting eligibility criteriaPostanesthesia Care Unit DeliriumShort Confusion Assessment MethodConfusion Assessment MethodOlder surgical patientsProspective cohort studyAnesthesiologists physical statusMultivariable logistic regressionMeeting eligibility criteriaSubjective memory impairmentOdds ratio analysisOlder patientsImplementation of the TaperGuard™ endotracheal tube in an unselected surgical population to reduce postoperative pneumonia
Martini RP, Yanez ND, Treggiari MM, Tekkali P, Soelberg C, Aziz MF. Implementation of the TaperGuard™ endotracheal tube in an unselected surgical population to reduce postoperative pneumonia. BMC Anesthesiology 2020, 20: 211. PMID: 32838740, PMCID: PMC7446207, DOI: 10.1186/s12871-020-01117-4.Peer-Reviewed Original ResearchConceptsPostoperative pneumoniaSubgroup of patientsBaseline cohortSurgical patientsIntervention cohortEndotracheal intubationOdds ratioNational Surgical Quality Improvement ProjectSurgical Quality Improvement ProjectUnselected surgical populationUnadjusted odds ratioHigh-risk populationPatient-level dataRisk of ventilatorQuality improvement projectInterrupted time series designElectronic health recordsHospital mortalityVAP bundleSurgical populationPatient characteristicsPneumonia riskHistoric cohortHospital admissionFurther risk reductionRandomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients
Harris WM, Treggiari MM, LeBlanc A, Giacomuzzi C, You JJ, Muralidaran A, Shen I. Randomized Pilot Trial of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 452-458. PMID: 32645767, DOI: 10.1177/2150135120923627.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgery patientsAcute normovolemic hemodilutionCardiac surgery patientsSecondary end pointsSurgery patientsEnd pointPostoperative outcomesUsual careBlood transfusionCardiac surgeryNormovolemic hemodilutionHeart surgeryBlood productsPilot trialPediatric heart surgery patientsMarkers of morbidityAllogenic blood transfusionPrimary end pointHeart surgery patientsLong-term morbidityBlood conservation strategiesWorse postoperative outcomesPediatric heart surgeryIntensive care unitBlood component therapyLabor Epidural Education and Hispanic Ethnicity: Reply.
Togioka BM, Yanez ND, Treggiari MM. Labor Epidural Education and Hispanic Ethnicity: Reply. Anesthesiology 2020, 132: 1284-1285. PMID: 32101970, DOI: 10.1097/aln.0000000000003201.Peer-Reviewed Original ResearchRandomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery
Togioka BM, Yanez D, Aziz MF, Higgins JR, Tekkali P, Treggiari MM. Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery. British Journal Of Anaesthesia 2020, 124: 553-561. PMID: 32139135, DOI: 10.1016/j.bja.2020.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCholinesterase InhibitorsDelayed Emergence from AnesthesiaDouble-Blind MethodFemaleHumansIntraoperative PeriodLung DiseasesMaleNeostigmineNeuromuscular BlockadeNeuromuscular JunctionNeuromuscular Nondepolarizing AgentsPatient ReadmissionPostoperative ComplicationsRocuroniumSugammadexConceptsPostoperative pulmonary complicationsResidual neuromuscular blockPulmonary complicationsDay hospital readmissionNeuromuscular blockPrimary endpointHospital readmissionDay hospital readmission rateOlder adultsHospital readmission ratesPhase 1 recoveryRocuronium reversalNeostigmine groupSecondary endpointsSugammadex groupReadmission ratesResidual paralysisSurgical closureSugammadexComplicationsNeostigmineLarger studySurgeryIncidenceEndpoint
2019
Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement.
Martin CS, Yanez ND, Treggiari MM, Piper L, Cusick J, Lalwani K. Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement. Minerva Anestesiologica 2019, 86: 141-149. PMID: 31808657, DOI: 10.23736/s0375-9393.19.13591-2.Peer-Reviewed Original ResearchConceptsMyringotomy tube placementIntraoperative acupunctureEmergence deliriumTube placementHeart 7PAED scoreMidazolam premedicationShen MenSevoflurane anesthesiaPediatric Anesthesia Emergence Delirium scaleASA physical status 1Standard anesthesia carePatient baseline characteristicsTrials of acupuncturePhysical status 1Standard of careIntravenous line placementBaseline characteristicsStatus 1Recovery roomSingle centerAnesthesia inductionDelirium scaleUniversity HospitalInhalational anesthesia