2017
Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologies
Rodríguez-Menéndez S, Fernández B, García M, Álvarez L, Fernández M, Sanz-Medel A, Coca-Prados M, Pereiro R, González-Iglesias H. Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologies. Talanta 2017, 178: 222-230. PMID: 29136815, DOI: 10.1016/j.talanta.2017.09.024.Peer-Reviewed Original Research
2015
Sensitive targeted multiple protein quantification based on elemental detection of Quantum Dots
Bustos A, Garcia-Cortes M, González-Iglesias H, Encinar J, Costa-Fernández JM, Coca-Prados M, Sanz-Medel A. Sensitive targeted multiple protein quantification based on elemental detection of Quantum Dots. Analytica Chimica Acta 2015, 879: 77-84. PMID: 26002480, DOI: 10.1016/j.aca.2015.03.015.Peer-Reviewed Original Research
2014
Quantitative selenium speciation by HPLC-ICP-MS(IDA) and simultaneous activity measurements in human vitreous humor
González de Vega R, Fernández-Sánchez ML, González Iglesias H, Coca Prados M, Sanz-Medel A. Quantitative selenium speciation by HPLC-ICP-MS(IDA) and simultaneous activity measurements in human vitreous humor. Analytical And Bioanalytical Chemistry 2014, 407: 2405-2413. PMID: 25344931, DOI: 10.1007/s00216-014-8241-6.Peer-Reviewed Original ResearchConceptsSize exclusion chromatographyMain selenium speciesQuantitative selenium speciationPlasma mass spectrometryQuantitative speciationSEC-ICPSelenium speciationSelenium speciesProtein complexesExclusion chromatographyExpected molecular weightSimultaneous activity measurementsMass spectrometryHPLC-ICPGPx proteinAntioxidant enzyme activitiesVitreous humor samplesICP-MSMolecular weightTotal Se concentrationEnzymatic activityPpb SeHuman vitreous humorEnzyme activityComplexesQuantitative bioimaging of trace elements in the human lens by LA-ICP-MS
Konz I, Fernández B, Fernández ML, Pereiro R, González-Iglesias H, Coca-Prados M, Sanz-Medel A. Quantitative bioimaging of trace elements in the human lens by LA-ICP-MS. Analytical And Bioanalytical Chemistry 2014, 406: 2343-2348. PMID: 24500754, DOI: 10.1007/s00216-014-7617-y.Peer-Reviewed Original ResearchConceptsMatrix-matched laboratory standardsMass spectrometryIsotope dilution mass spectrometryPlasma mass spectrometryDilution mass spectrometryHuman eye lensesAnalysis of FeDepth profiling analysisQuantitative bioimagingThin gold filmMatrix effectsExternal calibrationID-ICPLaser ablation cellQuantification purposesLA-ICPStandard solutionsGold filmCuSpectrometryHomogeneous distributionAblation cellLaser ablationFeMS
2013
Gold internal standard correction for elemental imaging of soft tissue sections by LA-ICP-MS: element distribution in eye microstructures
Konz I, Fernández B, Fernández ML, Pereiro R, González H, Álvarez L, Coca-Prados M, Sanz-Medel A. Gold internal standard correction for elemental imaging of soft tissue sections by LA-ICP-MS: element distribution in eye microstructures. Analytical And Bioanalytical Chemistry 2013, 405: 3091-3096. PMID: 23380953, DOI: 10.1007/s00216-013-6778-4.Peer-Reviewed Original ResearchConceptsElemental imagingInternal standardPlasma mass spectrometryInternal standard correctionMass spectrometryThin gold filmAnalytical potentialSample preparationInternal normalisationGold filmElement distributionLA-ICPLaser ablationCu distributionTrace element distributionGreat practical interestDonorsSpectrometry