2016
Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD)
Garcia M, Álvarez L, Fernandez Á, Gonzalez‐Iglesias H, Escribano J, Fernandez‐Vega B, Fernandez‐Vega Á, Villota E, Fernandez‐Vega L, Coca‐Prados M. Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD). Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0531.Peer-Reviewed Original ResearchAge-related macular degenerationSingle nucleotide polymorphismsMacular degenerationSignificant associationNorthern Spanish populationDry AMD casesHaploView 4.0 softwareNorthern Spanish patientsCase-control studySpanish populationUnique significant associationsPeripheral bloodHealthy controlsAMD subjectsMT2A geneSpanish patientsAllelic frequency analysisAMD casesConferring protectionPotential associationAllele GRs28366003Potential roleSignificant differencesMT genes
2015
CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age‐related macular degeneration
García M, Álvarez L, Nogacka AM, González-Iglesias H, Escribano J, Fernández-Vega B, Fernández-Vega Á, Fernández-Vega L, Coca-Prados M. CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age‐related macular degeneration. Acta Ophthalmologica 2015, 93: e658-e666. PMID: 26152901, DOI: 10.1111/aos.12790.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationSingle nucleotide polymorphismsRisk of AMDNorthern Spanish populationStrongest genetic risk factorHaploView 4.0 softwareNorthern Spanish patientsDifferent clinical formsCase-control studyComplement factor H (CFH) geneSpanish populationGenetic risk factorsRestriction fragment length polymorphismFactor H genePeripheral bloodClinical formsHealthy controlsRisk factorsSpanish patientsAllelic frequency analysisCFH polymorphismsCFH geneHaplotype CGGSignificant association
2014
Lysyl Oxidase‐Like 1 gene haplotypes and their association with pseudoexfoliation glaucoma in the Spanish population
ALVAREZ L, GARCIA M, GONZALEZ‐IGLESIAS H, ESCRIBANO J, RODRIGUEZ‐CALVO P, FERNANDEZ‐VEGA L, COCA‐PRADOS M. Lysyl Oxidase‐Like 1 gene haplotypes and their association with pseudoexfoliation glaucoma in the Spanish population. Acta Ophthalmologica 2014, 92: 0-0. DOI: 10.1111/j.1755-3768.2014.t075.x.Peer-Reviewed Original ResearchPseudoexfoliation glaucomaHaploView 4.0 softwareLOXL1 geneCase-control studyUnrelated healthy controlsSpanish populationGenetic variantsXFG patientsCase-control association studyHealthy controlsSpanish patientsAllelic frequency analysisPotential associationCommon genetic variantsLOXL1 SNPsPatientsRisk allelesXFGFragment length polymorphism analysisRestriction fragment length polymorphism analysisNext-generation sequencingGlaucomaGene haplotypesAssociationVariant frequency