2001
Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia
Pearlman J, Gertz Z, Wu Y, Simons M, Post M. Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia. Journal Of Computer Assisted Tomography 2001, 25: 558-562. PMID: 11473185, DOI: 10.1097/00004728-200107000-00008.Peer-Reviewed Original ResearchEfficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia
Sato K, Wu T, Laham R, Johnson R, Douglas P, Li J, Sellke F, Bunting S, Simons M, Post M. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Journal Of The American College Of Cardiology 2001, 37: 616-623. PMID: 11216988, DOI: 10.1016/s0735-1097(00)01144-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularInfusions, Intra-ArterialInfusions, IntravenousLymphokinesMaleMicrocirculationMyocardial ContractionMyocardial IschemiaSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsChronic myocardial ischemiaMyocardial ischemiaL-NAMEIntracoronary groupBlood flowNitro-L-arginine methyl ester hydrochlorideNitric oxide synthase inhibitionEndothelial growth factor treatmentLeft circumflex coronary arteryDose-limiting hypotensionOxide synthase inhibitionCircumflex coronary arteryVascular endothelial growth factor treatmentMyocardial blood flowRegional myocardial functionGrowth factor treatmentVEGF-induced angiogenesisIntravenous groupConcomitant administrationMicrovascular functionIntracoronary infusionCollateral indexDifferent regimensCoronary arteryIntravenous infusion
2000
Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia
Sato K, Laham R, Pearlman J, Novicki D, Sellke F, Simons M, Post M. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. The Annals Of Thoracic Surgery 2000, 70: 2113-2118. PMID: 11156130, DOI: 10.1016/s0003-4975(00)02018-x.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaRegional blood flowIschemic myocardiumFGF-2Myocardial ischemiaBlood flowPig modelML/min/Perfusion magnetic resonance imagingSingle intravenous infusionGrowth factor administrationRegional wall motionMagnetic resonance imagingAngiographic collateralsIntracoronary treatmentEjection fractionIntracoronary infusionIntravenous infusionIschemic areaFactor administrationMyocardial functionColored microspheresMyocardial perfusionResonance imagingTherapeutic angiogenesis
1999
Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results.
Garcia L, Baim D, Post M, Simons M, Laham R. Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results. Current Interventional Cardiology Reports 1999, 1: 222-227. PMID: 11096628.Peer-Reviewed Original ResearchTherapeutic angiogenesisClinical trialsClinical studiesPreclinical studiesSurgical accessSerious systemic adverse eventsSystemic adverse eventsIschemic heart diseaseMost clinical trialsChronic myocardial ischemiaThree-dimensional navigation systemMost preclinical studiesDelivery strategiesAngiogenic growth factorsAdverse eventsLocal therapyGeneral anesthesiaMyocardial ischemiaHeart diseaseFluoroscopic guidanceClinical usefulnessEndocardial approachSystemic recirculationAnimal modelsDelivery catheterTherapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies.
Laham R, Garcia L, Baim D, Post M, Simons M. Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies. Current Interventional Cardiology Reports 1999, 1: 228-233. PMID: 11096629.Peer-Reviewed Original ResearchVascular endothelial growth factorBasic fibroblast growth factorEndothelial growth factorGrowth factorFibroblast growth factorDouble-blind placebo-controlled trialIntravenous deliveryTherapeutic angiogenesisStandard revascularization proceduresPlacebo-controlled trialLarger patient populationChronic myocardial ischemiaDelivery strategiesPerivascular deliveryRevascularization proceduresPatient populationAtrial injectionIntrapericardial administrationTreatment modalitiesMyocardial ischemiaSustained administrationTreatment strategiesClinical studiesOutcome measuresIntramyocardial administration
1998
Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia
Lopez J, Edelman E, Stamler A, Hibberd M, Prasad P, Thomas K, Disalvo J, Caputo R, Carrozza J, Douglas P, Sellke F, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal Of Physiology 1998, 274: h930-h936. PMID: 9530206, DOI: 10.1152/ajpheart.1998.274.3.h930.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDisease Models, AnimalEndothelial Growth FactorsFibroblast Growth Factor 1Heart VentriclesLymphokinesMyocardial ContractionMyocardial IschemiaNeovascularization, PhysiologicRecombinant ProteinsSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsLeft ventricular functionChronic myocardial ischemiaVentricular functionCoronary flowMyocardial ischemia
1996
Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia
Sellke F, Li J, Stamler A, Lopez J, Thomas K, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996, 120: 182-188. PMID: 8751581, DOI: 10.1016/s0039-6060(96)80286-8.Peer-Reviewed Original ResearchConceptsCollateral-dependent LCx regionAcidic fibroblast growth factorFibroblast growth factorLCx regionBlood flowSodium nitroprussideProximal left circumflex coronary arterySevere coronary artery diseaseLeft circumflex coronary arteryGrowth factorCoronary arterial microvesselsCoronary microvascular reactivityProximal (<b>d</b>) LCX arteryEndothelium-dependent mechanismEndothelium-dependent relaxationCircumflex coronary arteryCollateral-dependent myocardiumCoronary artery diseaseTreatment of patientsGuanylate cyclase activators sodium nitroprussideChronic myocardial ischemiaAdenylate cyclase activator forskolinPeriadventitial administrationCyclase activator forskolinMicrovascular reactivityPerivascular delivery of prolonged half-life aFGF via EVAC results in angiographic collateral development, improvement in coronary flow and function in chronic myocardial ischemia
Lopez J, Edelman E, Stambler A, Thomas K, D'Salvo J, Hibberd M, Caputo R, Carrozza J, Douglas P, Sellke F, Simons M. Perivascular delivery of prolonged half-life aFGF via EVAC results in angiographic collateral development, improvement in coronary flow and function in chronic myocardial ischemia. Journal Of The American College Of Cardiology 1996, 27: 30. DOI: 10.1016/s0735-1097(96)80309-3.Peer-Reviewed Original ResearchChronic myocardial ischemia