A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 2014, 24: 473-483. PMID: 24530065, PMCID: PMC3949122, DOI: 10.1016/j.cub.2014.01.013.Peer-Reviewed Original ResearchConceptsTransient receptor potential ankyrin 1Ion channel modifiersProTxIon channel transient receptor potential ankyrin 1Channel modifiersPeptide toxinsSpecific peptidesIon channelsVoltage-gated sodium channelsContext of painS1-S4Spider venomPotential clinical applicationsTRPA1 antagonistTRPA1 functionAnkyrin 1PeptidesModifiersPeptide antagonistAntagonistSodium channelsPharmacological reagentsReagentsClinical applicationNav1.2