1991
Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial.
Bracken M. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. Journal Of Neurotrauma 1991, 8 Suppl 1: s47-50; discussion s51-2. PMID: 1920461.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryAdministration of methylprednisoloneApparent contraindicationsNeurological improvementClinical trialsPermanent paralysisMethylprednisoloneLow dosesInjuryAdministrationDosesTrialsTreatmentMulticenterPlaceboContraindicationsNaloxoneParalysisDose
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose