2021
CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus
Graziano VR, Alfajaro MM, Schmitz CO, Filler RB, Strine MS, Wei J, Hsieh LL, Baldridge MT, Nice TJ, Lee S, Orchard RC, Wilen CB. CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus. Journal Of Virology 2021, 95: 10.1128/jvi.01652-20. PMID: 33177207, PMCID: PMC7925115, DOI: 10.1128/jvi.01652-20.Peer-Reviewed Original ResearchConceptsConditional knockout miceIntestinal epithelial cellsCell tropismKnockout miceTuft cellsDendritic cellsMyelomonocytic cellsB cellsCellular tropismMurine norovirusEpithelial cellsViral RNA levelsInnate immune responseCause of gastroenteritisMNoV infectionCell typesViral loadGastrointestinal infectionsReceptor expressionImmunocompetent humansImmune responseCell type-specific rolesMouse modelIntestinal tissueMNoV
2016
Pathogenesis of Korean SapelovirusA in piglets and chicks
Kim D, Kang M, Son K, Bak G, Park J, Hosmillo M, Seo J, Kim J, Alfajaro M, Soliman M, Baek Y, Cho E, Lee J, Kwon J, Choi J, Goodfellow I, Cho K. Pathogenesis of Korean SapelovirusA in piglets and chicks. Journal Of General Virology 2016, 97: 2566-2574. PMID: 27487773, PMCID: PMC5078829, DOI: 10.1099/jgv.0.000571.Peer-Reviewed Original ResearchConceptsExtra-intestinal organsHigher viral RNA levelsNon-suppurative myelitisViral RNA levelsReal-time reverse transcription PCRCells of pigsIntestinal pathologyReverse transcription-PCRViral antigensViral pathogenesisReproductive disordersSapelovirus APathogenesisPorcine sapelovirusVirus entryCultured cell linesRNA levelsEpithelial cellsTranscription-PCRFecal samplesPigletsPneumoniaCell linesSialic acidPathology