2020
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal Of Experimental Medicine 2020, 217: e20201241. PMID: 32750141, PMCID: PMC7401025, DOI: 10.1084/jem.20201241.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCell Line, TumorCoronavirus InfectionsCOVID-19DependovirusDisease Models, AnimalFemaleHumansInflammationInterferon Type ILungMaleMiceMice, Inbred C57BLMice, TransgenicPandemicsParvoviridae InfectionsPeptidyl-Dipeptidase APneumonia, ViralSARS-CoV-2Signal TransductionVirus ReplicationConceptsSARS-CoV-2Type I interferonMouse modelI interferonRobust SARS-CoV-2 infectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 infectionRespiratory syndrome coronavirus 2SARS-CoV-2 replicationCOVID-19 patientsSyndrome coronavirus 2Patient-derived virusesSignificant fatality ratePathological findingsInflammatory rolePathological responseEnzyme 2Receptor angiotensinFatality rateVaccine developmentGenetic backgroundViral replicationCoronavirus diseaseMice
2011
Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC/Nga mice
Collantes T, Rho M, Kwon H, Jung B, Alfajaro M, Kim D, Kim H, Hosmillo M, Park J, Son K, Park S, Kang M, Park S, Lee S, Lee W, Cho K. Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC/Nga mice. Food Chemistry 2011, 132: 1269-1275. PMID: 29243610, DOI: 10.1016/j.foodchem.2011.11.100.Peer-Reviewed Original ResearchNC/Nga miceAD-like skin lesionsSerum IgE levelsSkin lesionsIgE levelsPeripheral leucocytesAtopic dermatitis-like skin lesionsLike skin lesionsEffective alternative therapyTumor necrosis factorDose-dependent mannerHistological skin lesionsMRNA expression levelsRelative mRNA expressionEosinophil ratioAtopic dermatitisImmune mediatorsInflammatory cytokinesAlternative therapiesNecrosis factorMast cellsContinuous ingestionLesionsMRNA expressionMice