2015
The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea
Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH. The Use of a Fully Automated Automatic Adaptive Servoventilation Algorithm in the Acute and Long-term Treatment of Central Sleep Apnea. CHEST Journal 2015, 148: 1454-1461. PMID: 25950507, DOI: 10.1378/chest.14-2966.Peer-Reviewed Original ResearchConceptsCentral apnea indexApnea-hypopnea indexCentral sleep apneaSleep apneaSleep qualityComplex sleep-disordered breathingASV deviceASV titrationAdaptive servoventilation devicesCongestive heart failureMonths of treatmentSleep-disordered breathingEpworth Sleepiness ScaleLong-term treatmentImproved sleep qualityMixed sleep apneaBetter sleep qualityApnea indexHeart failureObservational trialObstructive apneaBreathing disordersInspiratory pressureArousal indexDaytime sleepiness
1989
Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea
Hanly P, George C, Millar T, Kryger M. Heart Rate Response to Breath-Hold, Valsalva and Mueller Maneuvers in Obstructive Sleep Apnea. CHEST Journal 1989, 95: 735-739. PMID: 2924602, DOI: 10.1378/chest.95.4.735.Peer-Reviewed Original ResearchConceptsVoluntary respiratory maneuversObstructive sleep apneaHR responseSleep apneaRespiratory maneuversMueller maneuverOxygen saturationVagal toneAbsence of hypoxemiaArterial oxygen saturationHeart rate responseObstructive apneaMouth pressureApneaHR changesMale subjectsRate responseBreath holdSimilar durationValsalvaSignificant differencesSignificant correlationOSASMajor determinantWakefulness
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. Bulletin Européen De Physiopathologie Respiratoire 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Central Apnea
Kryger M. Central Apnea. JAMA Internal Medicine 1982, 142: 1793-1794. PMID: 7125764, DOI: 10.1001/archinte.1982.00340230033005.Peer-Reviewed Original ResearchConceptsCentral apneaObstructive apneaSleep apneaMixed apneaSevere gas exchange abnormalitiesBrain stem diseaseCentral sleep apneaGas exchange abnormalitiesRespiratory muscle contractionAdult patientsAnatomic obstructionUpper airwayBrain stemPhysiologic findingsApneaPatientsMuscle contractionHypoventilationDiseaseVast majorityAirwayObstructionAbnormalitiesSleep