1983
Sighs During Sleep in Adult Humans
Perez-Padilla R, West P, Kryger M. Sighs During Sleep in Adult Humans. Sleep 1983, 6: 234-243. PMID: 6622880, DOI: 10.1093/sleep/6.3.234.Peer-Reviewed Original ResearchConceptsSleep stage changesCentral apneaGreat intersubject variationExpiratory flowRespiratory centerInspiratory flowEMG activityHeart rateRespiratory rateNormal adultsRespiratory cycleSleepIntersubject variationAdult humansRespiratory controlSleep stagesEEG frequenciesStage 1Normal variabilityPrevious breathStage changesSighsArousalHypoventilationApnea
1982
Central Apnea
Kryger M. Central Apnea. JAMA Internal Medicine 1982, 142: 1793-1794. PMID: 7125764, DOI: 10.1001/archinte.1982.00340230033005.Peer-Reviewed Original ResearchConceptsCentral apneaObstructive apneaSleep apneaMixed apneaSevere gas exchange abnormalitiesBrain stem diseaseCentral sleep apneaGas exchange abnormalitiesRespiratory muscle contractionAdult patientsAnatomic obstructionUpper airwayBrain stemPhysiologic findingsApneaPatientsMuscle contractionHypoventilationDiseaseVast majorityAirwayObstructionAbnormalitiesSleep