2023
A Patient with an Unusual Cause of AKI and Scrotal Swelling
Gomez D, Perazella M. A Patient with an Unusual Cause of AKI and Scrotal Swelling. Kidney360 2023, 4: 1188-1189. PMID: 37651667, PMCID: PMC10484347, DOI: 10.34067/kid.0000000000000125.Peer-Reviewed Original ResearchContrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction?
Davenport M, Perazella M, Nallamothu B. Contrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction? Circulation 2023, 147: 847-849. PMID: 36913495, DOI: 10.1161/circulationaha.122.062783.Peer-Reviewed Original Research
2022
Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
Kanbay M, Yildiz AB, Siriopol D, Vehbi S, Hasbal NB, Kesgin YE, Celayir M, Selcukbiricik F, Covic A, Perazella MA. Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis. International Urology And Nephrology 2022, 55: 1025-1032. PMID: 36282399, DOI: 10.1007/s11255-022-03395-y.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryHumansImmune Checkpoint InhibitorsKidneyNeoplasmsPrognosisRetrospective StudiesRisk FactorsConceptsAcute kidney injuryImmune checkpoint inhibitorsSolid organ malignanciesCheckpoint inhibitorsKidney injuryOrgan malignanciesNephrotoxic agentsSingle-center retrospective cohort studyType of ICIBaseline serum creatinine levelAcute interstitial nephritisLocation of malignancyRetrospective cohort studySerum creatinine levelsKidney function recoveryRenal replacement therapyUrinary tract obstructionRisk of mortalityICPI treatmentRenal prognosisTract obstructionCohort studyCreatinine levelsFive patientsInterstitial nephritisDiagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Sprangers B, Leaf DE, Porta C, Soler MJ, Perazella MA. Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury. Nature Reviews Nephrology 2022, 18: 794-805. PMID: 36168055, DOI: 10.1038/s41581-022-00630-8.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsAcute kidney injuryKidney injuryKidney biopsyAcute tubulo-interstitial nephritisImmune-related adverse eventsConcomitant anticancer therapyTubulo-interstitial nephritisEffector T cellsEvaluation of patientsLoss of toleranceCheckpoint inhibitorsPartial remissionPermanent discontinuationAdverse eventsMost patientsAppropriate treatmentEarly initiationT cellsClinical practiceFavorable responsePatientsAccurate diagnosisCancer treatmentAnticancer therapyDrug-Induced Acute Kidney Injury
Perazella MA, Rosner MH. Drug-Induced Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1220-1233. PMID: 35273009, PMCID: PMC9435983, DOI: 10.2215/cjn.11290821.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryHumansInflammationKidneyKidney Tubules, ProximalNephritis, InterstitialConceptsKidney injuryTubular injuryDrug-induced acute kidney injuryT cell-mediated immune responsesDrug-related kidney injuryCell-mediated immune responsesAcute interstitial nephritisDirect tubular injuryTreatment of AKIAcute kidney injuryAcute tubular injuryIntensive care unitInduction of inflammationAKI riskIntratubular obstructionTubulointerstitial injuryInterstitial nephritisCare unitInflammation leadInjury resultsCommon causeImmune responseHospital wardsProximal tubulesAKIMortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCreatinineHumansImmune Checkpoint InhibitorsKidneyNephritis, InterstitialConceptsAcute interstitial nephritisAcute kidney injuryImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyICI therapyKidney injuryInhibitor therapyInterstitial nephritisTime-varying Cox proportional hazards modelsHigher peak serum creatinineSevere acute kidney injuryCancer typesCox proportional hazards modelAssociations of biopsyBaseline laboratory valuesObservational cohort studyPeak serum creatinineFavorable treatment responseProportional hazards modelAKI patientsTherapy initiationCohort studySerum creatinineUnivariable analysisImmune activationSevere AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection
Rehan A, Moeckel GW, Perazella MA. Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Kidney360 2022, 3: 405-406. PMID: 35373119, PMCID: PMC8967631, DOI: 10.34067/kid.0006102021.Peer-Reviewed Original Research
2021
Immunotherapy-Related Acute Kidney Injury
Manohar S, Jhaveri KD, Perazella MA. Immunotherapy-Related Acute Kidney Injury. Advances In Kidney Disease And Health 2021, 28: 429-437.e1. PMID: 35190109, DOI: 10.1053/j.ackd.2021.07.006.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyEffective immune checkpoint inhibitorsAcute kidney injuryImmune checkpoint inhibitorsHigh-dose interleukinNumerous clinical trialsT-cell therapyField of oncologyCheckpoint inhibitorsKidney injuryGeneration immunotherapiesClinical trialsClinical practiceImmunotherapyImmune systemAdverse effectsNephrotoxicityInterleukinPathophysiologyInjuryTherapyCancerOncologyTrials
2020
Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary.
Perazella M. Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary. Kidney360 2020, 1: 166-168. PMID: 35378019, PMCID: PMC8809261, DOI: 10.34067/kid.0001072019.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiopsyFemaleHumansImmune Checkpoint InhibitorsKidneyMaleNephritis, InterstitialNomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference
Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Hoorn EJ, Ingelfinger JR, Inker LA, Levin A, Mehrotra R, Palevsky PM, Perazella MA, Tong A, Allison SJ, Bockenhauer D, Briggs JP, Bromberg JS, Davenport A, Feldman HI, Fouque D, Gansevoort RT, Gill JS, Greene EL, Hemmelgarn BR, Kretzler M, Lambie M, Lane PH, Laycock J, Leventhal SE, Mittelman M, Morrissey P, Ostermann M, Rees L, Ronco P, Schaefer F, St Clair Russell J, Vinck C, Walsh SB, Weiner DE, Cheung M, Jadoul M, Winkelmayer WC. Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney International 2020, 97: 1117-1129. PMID: 32409237, DOI: 10.1016/j.kint.2020.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAlbuminuriaGlomerular Filtration RateHumansKidneyRenal Insufficiency, ChronicConceptsAcute kidney injuryChronic kidney diseaseGlomerular filtration rateKidney diseaseKidney functionKDIGO definitionConsensus conferenceSeverity of CKDEnd-stage kidney diseaseAcute kidney diseaseAbsence of symptomsGlobal Outcomes (KDIGO) Consensus ConferenceKDIGO guidelinesKidney injuryKidney failureKidney measuresFiltration rateWorldwide burdenGlobal outcomeKidney structureDiseaseHealth communitySeverityFollowing recommendationsMore effective communicationIs urine microscopy a useful early biomarker for cardiac surgeryrelated AKI?
Perazella MA. Is urine microscopy a useful early biomarker for cardiac surgeryrelated AKI? Brazilian Journal Of Nephrology 2020, 42: 1-3. PMID: 32129787, PMCID: PMC7213936, DOI: 10.1590/2175-8239-jbn-2019-0208.Peer-Reviewed Original ResearchSGLT2 inhibitor therapy in patients with type-2 diabetes mellitus: is acute kidney injury a concern?
Baker ML, Perazella MA. SGLT2 inhibitor therapy in patients with type-2 diabetes mellitus: is acute kidney injury a concern? Journal Of Nephrology 2020, 33: 985-994. PMID: 32067179, DOI: 10.1007/s40620-020-00712-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcute Kidney InjuryDiabetes Mellitus, Type 2HumansPharmaceutical PreparationsSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsConceptsType 2 diabetes mellitusAcute kidney injuryChronic kidney diseaseDiabetes mellitusKidney diseaseKidney injuryAlbuminuric chronic kidney diseaseEnd-stage kidney diseaseInhibitor drugsSGLT2 inhibitor therapySignificant cardiovascular benefitsHeart failure hospitalizationGlomerular filtration rateAtherosclerotic cardiovascular diseaseLarge clinical trialsFDA adverse eventsBeneficial cardiovascularKidney benefitsSGLT2 transporterCardiovascular deathFailure hospitalizationAdverse eventsCardiovascular benefitsKidney protectionBlood pressureUse of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation
Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, Rodby RA, Wang CL, Weinreb JC. Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Radiology 2020, 294: 192094. PMID: 31961246, DOI: 10.1148/radiol.2019192094.Peer-Reviewed Original ResearchConceptsAcute kidney injuryGlomerular filtration rateContrast mediumKidney diseaseFiltration rateContrast-associated acute kidney injuryContrast-induced acute kidney injuryIntravenous normal salineReduced kidney functionSevere kidney diseaseNational Kidney FoundationIodinated Contrast MediaHigh-risk circumstancesSimultaneous joint publicationCI-AKIKidney injuryMaintenance dialysisKidney functionOrdering clinicianNormal salineConsensus statementKidney FoundationTreatment responseAmerican CollegePatients
2019
Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation
Renaghan AD, Jaimes EA, Malyszko J, Perazella MA, Sprangers B, Rosner MH. Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation. Clinical Journal Of The American Society Of Nephrology 2019, 15: 289-297. PMID: 31836598, PMCID: PMC7015091, DOI: 10.2215/cjn.08580719.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCell transplantationKidney injuryHepatic sinusoidal obstruction syndromeAcute kidney injurySinusoidal obstruction syndromeCongenital immune deficiencyDevelopment of CKDType of transplantNonmalignant hematologic disordersStem cell transplantLife-saving therapySickle cell diseaseHigh mortality rateAcute dialysisNephrotoxic medicationsNonrelapse mortalityConditioning regimenHost diseaseInfusion syndromeObstruction syndromeThrombotic microangiopathyTransplant recipientsPatient characteristics
2015
The Urine Sediment as a Biomarker of Kidney Disease
Perazella MA. The Urine Sediment as a Biomarker of Kidney Disease. American Journal Of Kidney Diseases 2015, 66: 748-755. PMID: 25943719, DOI: 10.1053/j.ajkd.2015.02.342.Peer-Reviewed Original ResearchConceptsUrine sediment examinationKidney diseaseSediment examinationKidney conditionsUrine sedimentNovel urine biomarkersNew candidate biomarkersCentralized laboratory testingKidney injuryUrine biomarkersNew diagnostic technologiesUrinary biomarkersClinical practiceCandidate biomarkersTime-honored testsMaintenance of competencyDiagnostic panelDiagnostic testsDiseaseBiomarkersCliniciansUseful batteryExaminationDiagnostic informationDiagnostic technologies
2009
Acute phosphate nephropathy
Markowitz GS, Perazella MA. Acute phosphate nephropathy. Kidney International 2009, 76: 1027-1034. PMID: 19675530, DOI: 10.1038/ki.2009.308.Peer-Reviewed Original ResearchConceptsAcute phosphate nephropathyAcute kidney injuryChronic kidney diseasePhosphate nephropathySubsequent chronic renal failureChronic tubular injuryAngiotensin receptor blockersChronic renal failureHigh-risk patientsRenal biopsy findingsClinical-pathological entityAggressive hydrationKidney injuryReceptor blockersBiopsy findingsRenal failureTubular injuryKidney diseasePathological entityRisk factorsFemale genderDistal tubulesEpidemiologic studiesDistal nephronEnzyme inhibitors
2001
COX-2 Inhibitors and the Kidney
Perazella M. COX-2 Inhibitors and the Kidney. Hospital Practice 2001, 36: 43-56. PMID: 11263799, DOI: 10.3810/hp.2001.03.230.Peer-Reviewed Original Research
2000
Acute Renal Failure in HIV-Infected Patients: A Brief Review of Common Causes
Perazella M. Acute Renal Failure in HIV-Infected Patients: A Brief Review of Common Causes. The American Journal Of The Medical Sciences 2000, 319: 385-391. DOI: 10.1016/s0002-9629(15)40779-7.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAcute renal failureRenal failureCommon causeAcute renal insufficiencyTumor lysis syndromeRenal tubular functionNephrotoxic medicationsPostrenal azotemiaLysis syndromePrerenal azotemiaRenal insufficiencyCrystal nephropathyNephrotoxic insultsTubular functionImmunodeficiency virusIschemic processIntravascular volumeGlomerular diseaseAllergic reactionsRenal syndromeUrinary systemPatientsRenal tubulesGlomerular capillaries
1999
Crystal-induced acute renal failure
Perazella M. Crystal-induced acute renal failure. The American Journal Of Medicine 1999, 106: 459-465. PMID: 10225250, DOI: 10.1016/s0002-9343(99)00041-8.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcyclovirHumansIndinavirKidneyMethotrexateRiskSulfonamidesTriamtereneConceptsAcute renal failureRenal insufficiencyRenal failureVolume repletionAppropriate drug dosingIntrarenal crystal depositionAcute renal insufficiencyIntravascular volume depletionAdditional risk factorsHigh urinary flowDialytic supportUrinary flowRisk factorsVolume depletionDrug dosingDrug dosesCrystal depositionIntratubular precipitationInsufficiencyUrineMedicationsRepletionFurther exposureFailureHuman urineExtreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen
Orias M, Mahnensmith R, Perazella M. Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen. American Journal Of Nephrology 1999, 19: 60-63. PMID: 10085452, DOI: 10.1159/000013427.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAcute Kidney InjuryAdministration, OralAgedCatharticsHumansMalePhosphatesRenal DialysisConceptsAcute renal failureRenal failureOliguric acute renal failureBowel-cleansing preparationsBowel-cleansing regimenBowel regimenExtreme hyperphosphatemiaHypocalcemic tetanyGastrointestinal proceduresRenal excretionGastrointestinal transitPatientsIntoxicationRegimenFailureHyperphosphatemiaRegimensExcretionDiseaseTetany