2020
Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events
Herrmann SM, Perazella MA. Immune Checkpoint Inhibitors and Immune-Related Adverse Renal Events. Kidney International Reports 2020, 5: 1139-1148. PMID: 32775813, PMCID: PMC7403510, DOI: 10.1016/j.ekir.2020.04.018.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsAcute kidney injuryCheckpoint inhibitorsAdverse renal effectsAdverse renal eventsSubset of patientsPotential risk factorsAcute rejectionRenal eventsKidney injuryRenal effectsTransplant populationRenal toxicityRisk factorsBetter outcomesPatientsNephrotoxicityCliniciansCancer therapyCancerRecent studiesInhibitorsCurrent informationComplicationsProviders
2017
Update on the Renal Effects of Anticancer Agents
Perazella M. Update on the Renal Effects of Anticancer Agents. Journal Of Onco-Nephrology 2017, 1: 170-178. DOI: 10.5301/jo-n.5000026.Peer-Reviewed Original ResearchAnticancer drug nephrotoxicityChronic kidney injuryKidney injuryDrug nephrotoxicityAcute interstitial nephritisAcute kidney injuryAcute tubular injuryNumber of drugsNumber of lesionsAcid-base disturbancesNephrology updateRenal effectsNovel immunotherapiesTubular injuryInterstitial nephritisGlomerular injuryKidney diseaseCancer patientsConventional chemotherapyRenal metabolismSystemic toxicityInjuryNephrotoxicityChemotherapeutic drugsPatientsCrizotinib: Renal Safety Evaluation
Perazella M, Izzedine H. Crizotinib: Renal Safety Evaluation. Journal Of Onco-Nephrology 2017, 1: 49-56. DOI: 10.5301/jo-n.5000012.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced ALK-positive non-small cell lung cancerALK-positive non-small cell lung cancerPositive non-small cell lung cancerAnaplastic lymphoma kinase-1Renal adverse effectsAcute kidney injuryAdverse renal effectsInsulin receptor tyrosine kinase familyCell lung cancerMechanism of actionKidney injuryPeripheral edemaRenal effectsElectrolyte disordersLung cancerClinical indicationsClinical trialsRenal cystsALK inhibitorsReceptor tyrosine kinase familySmall molecule inhibitorsCrizotinibClinical useAdverse effects
2008
Proton pump inhibitors: acute interstitial nephritis and other renal effects
Brewster U, Perazella M. Proton pump inhibitors: acute interstitial nephritis and other renal effects. 2008, 567-577. DOI: 10.1007/978-0-387-84843-3_25.Peer-Reviewed Original ResearchAcute interstitial nephritisProton pump inhibitorsInterstitial nephritisEnd-stage renal diseaseAnti-ulcer therapyChronic interstitial nephritisChronic interstitial diseaseDrug-drug interactionsRenal complicationsRenal effectsRenal diseasePump inhibitorsEfficacy profileInterstitial diseaseNephritisPrescribed classOmeprazoleDisease
2001
COX-2 Inhibitors and the Kidney
Perazella M. COX-2 Inhibitors and the Kidney. Hospital Practice 2001, 36: 43-56. PMID: 11263799, DOI: 10.3810/hp.2001.03.230.Peer-Reviewed Original ResearchNSAIDs and the Kidney Revisited: Are Selective Cyclooxygenase-2 Inhibitors Safe?
Eras J, Perazella M. NSAIDs and the Kidney Revisited: Are Selective Cyclooxygenase-2 Inhibitors Safe? The American Journal Of The Medical Sciences 2001, 321: 181-190. PMID: 11269794, DOI: 10.1097/00000441-200103000-00005.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsCOX-2 selective inhibitorsSelective cyclooxygenase-2 inhibitorRenal effectsCyclooxygenase-2 inhibitorNonselective nonsteroidal anti-inflammatory drugsSelective nonsteroidal anti-inflammatory drugsSelective COX-2 inhibitorsAdverse renal effectsBaseline patient characteristicsAdverse gastrointestinal effectsCOX-1/COXCyclooxygenase enzyme activityAnti-inflammatory drugsCOX-2 inhibitorsCOX-2 enzymePatient characteristicsGastrointestinal effectsChronic painGastric erosionsInflammatory conditionsClinical studiesClinical investigationKidney tissueKidney