2024
Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2021
The Crystalline Nephropathies
Perazella MA, Herlitz LC. The Crystalline Nephropathies. Kidney International Reports 2021, 6: 2942-2957. PMID: 34901567, PMCID: PMC8640557, DOI: 10.1016/j.ekir.2021.09.003.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseKidney injuryCrystalline nephropathyKidney diseaseCrystal depositionFurther kidney injuryIntrarenal crystal depositionUrinary sediment findingsUrine sediment examinationTubular obstructionHistologic findingsPathologic aspectsNephropathyClinical standpointInjuryTubular luminaSediment examinationFluid physiologyIdentification of crystalsCliniciansDiseaseIndirect cytotoxicityBiopsyInflammationImmunotherapy-Related Acute Kidney Injury
Manohar S, Jhaveri KD, Perazella MA. Immunotherapy-Related Acute Kidney Injury. Advances In Kidney Disease And Health 2021, 28: 429-437.e1. PMID: 35190109, DOI: 10.1053/j.ackd.2021.07.006.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyEffective immune checkpoint inhibitorsAcute kidney injuryImmune checkpoint inhibitorsHigh-dose interleukinNumerous clinical trialsT-cell therapyField of oncologyCheckpoint inhibitorsKidney injuryGeneration immunotherapiesClinical trialsClinical practiceImmunotherapyImmune systemAdverse effectsNephrotoxicityInterleukinPathophysiologyInjuryTherapyCancerOncologyTrials
2020
Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary.
Perazella M. Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: Commentary. Kidney360 2020, 1: 166-168. PMID: 35378019, PMCID: PMC8809261, DOI: 10.34067/kid.0001072019.Peer-Reviewed Original Research
2019
Diagnosing acute interstitial nephritis: considerations for clinicians
Nussbaum E, Perazella M. Diagnosing acute interstitial nephritis: considerations for clinicians. Clinical Kidney Journal 2019, 12: 808-813. DOI: 10.1093/ckj/sfz080.Peer-Reviewed Original ResearchAcute interstitial nephritisAcute kidney injuryAcute tubular necrosisInterstitial nephritisCommon causeDirect further managementKidney injuryMost patientsTubular necrosisKidney biopsyClinical historyFurther managementCliniciansLaboratory dataNephritisPatientsInjuryDiagnosisSingle testCauseBiopsyNecrosisBiomarkers
2018
Drug-Induced Acute Kidney Injury
Luciano R, Perazella M. Drug-Induced Acute Kidney Injury. 2018, 145-163. DOI: 10.1007/978-1-4939-8628-6_9.Peer-Reviewed Original ResearchDrug-induced acute kidney injuryAcute kidney injuryKidney injuryAcute tubular injury/necrosisAcute interstitial nephritisFocal segmental glomerulosclerosisDrugs/substancesOsmotic nephropathyRisk patientsInterstitial nephritisKidney functionPrescribed medicationsSegmental glomerulosclerosisEarly identificationRenal compartmentsInjuryHarmful drugsTherapeutic agentsAdverse effectsCommon formDrugsMedicationsKidneyCommon problemDiagnostic agents
2017
Update on the Renal Effects of Anticancer Agents
Perazella M. Update on the Renal Effects of Anticancer Agents. Journal Of Onco-Nephrology 2017, 1: 170-178. DOI: 10.5301/jo-n.5000026.Peer-Reviewed Original ResearchAnticancer drug nephrotoxicityChronic kidney injuryKidney injuryDrug nephrotoxicityAcute interstitial nephritisAcute kidney injuryAcute tubular injuryNumber of drugsNumber of lesionsAcid-base disturbancesNephrology updateRenal effectsNovel immunotherapiesTubular injuryInterstitial nephritisGlomerular injuryKidney diseaseCancer patientsConventional chemotherapyRenal metabolismSystemic toxicityInjuryNephrotoxicityChemotherapeutic drugsPatients
2015
Drug-Induced Glomerular Disease: Direct Cellular Injury
Markowitz GS, Bomback AS, Perazella MA. Drug-Induced Glomerular Disease: Direct Cellular Injury. Clinical Journal Of The American Society Of Nephrology 2015, 10: 1291-1299. PMID: 25862776, PMCID: PMC4491280, DOI: 10.2215/cjn.00860115.Peer-Reviewed Original ResearchConceptsGlomerular diseaseCell injuryGlomerular lesionsNonsteroidal anti-inflammatory drugsAcute interstitial nephritisDrug-induced etiologyPotential of medicationsRenal function recoveryAcute tubular necrosisEndothelial cell injuryMesangial cell injuryEpithelial cell injuryAnti-inflammatory drugsDirect cellular injuryRapid discontinuationKidney injuryTubular necrosisAntiplatelet agentsInterstitial nephritisTubulointerstitial compartmentFunction recoveryIatrogenic formCellular injuryAntiangiogenesis drugsInjuryNew drug toxicities in the onco-nephrology world
Perazella MA, Izzedine H. New drug toxicities in the onco-nephrology world. Kidney International 2015, 87: 909-917. PMID: 25671763, DOI: 10.1038/ki.2015.30.Peer-Reviewed Original ResearchConceptsKidney injuryAnticancer medicationsAdverse renal consequencesAcute kidney injuryChronic kidney diseaseLevel of proteinuriaMore effective therapiesRenal consequencesElectrolyte disturbancesKidney diseaseNephrotoxic effectsNephrotoxic potentialRisk factorsEffective therapyNephrotoxic manifestationsDrug toxicityNew agentsOld drugsNephrology communityResistant cancersClinical arenaAvailable evidenceMedicationsPatientsInjury
2009
Renal Vulnerability to Drug Toxicity
Perazella MA. Renal Vulnerability to Drug Toxicity. Clinical Journal Of The American Society Of Nephrology 2009, 4: 1275-1283. PMID: 19520747, DOI: 10.2215/cjn.02050309.Peer-Reviewed Original ResearchConceptsDrug-induced kidney diseaseKidney diseaseRenal vulnerabilityRisk factorsAcute kidney injuryChronic kidney diseaseDrug-related factorsProteinuric renal diseaseKidney injuryRenal complicationsRenal injuryRenal diseaseNephrotoxic effectsRenal syndromeDrug toxicityDiseaseInjuryKidneyDrugsFactor categoriesToxinComplicationsPatientsFactorsTubulopathy
1997
Renal insufficiency after intravenous immune globulin therapy: a report of two cases and an analysis of the literature.
Cayco A, Perazella M, Hayslett J. Renal insufficiency after intravenous immune globulin therapy: a report of two cases and an analysis of the literature. Journal Of The American Society Of Nephrology 1997, 8: 1788-94. PMID: 9355083, DOI: 10.1681/asn.v8111788.Peer-Reviewed Original ResearchConceptsIntravenous immune globulin therapyAcute renal failureImmune globulin therapyGlobulin therapyRenal replacement therapyNumber of complicationsIVIG treatmentRenal insufficiencyRenal failureRenal injuryIVIG preparationsSuch patientsReplacement therapyClinical disordersTherapyCases recoveryComplicationsPatientsRecurrenceWidespread useInjuryInsufficiencyAgentsCasesBone marrow transplant nephropathy: a case report and review of the literature.
Cruz D, Perazella M, Mahnensmith R. Bone marrow transplant nephropathy: a case report and review of the literature. Journal Of The American Society Of Nephrology 1997, 8: 166-73. PMID: 9013462, DOI: 10.1681/asn.v81166.Peer-Reviewed Original ResearchConceptsBone marrow transplant nephropathyBone marrow transplantationRenal injuryTransplant nephropathyMarrow transplantationLate renal injuryEarly renal injuryHemolytic uremic syndromeVariety of causesNephrotoxic medicationsRenal failurePathologic featuresCase reportUremic syndromeLate effectsRadiation therapyRenal syndromeSyndromeNephropathySubsequent treatmentTransplantationInjuryMedicationsChemotherapyReview
1993
Renal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia
Perazella M, Eisen R, Frederick W, Brown E. Renal Failure and Severe Hypokalemia Associated With Acute Myelomonocytic Leukemia. American Journal Of Kidney Diseases 1993, 22: 462-467. PMID: 8372846, DOI: 10.1016/s0272-6386(12)70154-3.Peer-Reviewed Original ResearchConceptsAcute myelomonocytic leukemiaRenal failureMyelomonocytic leukemiaRenal parenchymal infiltrationRenal tubular injuryHypokalemia AssociatedInappropriate kaliuresisMicrovascular insufficiencyRenal insufficiencySevere hypokalemiaTubular injuryParenchymal infiltrationSetting of leukemiaBlast cellsLeukemiaMetabolic perturbationsHypokalemiaVariety of mechanismsInsufficiencyFailureLeukostasisKaliuresisEtiologyInjury