2001
Myosin-VIIb, a Novel Unconventional Myosin, Is a Constituent of Microvilli in Transporting Epithelia
Chen Z, Hasson T, Zhang D, Schwender B, Derfler B, Mooseker M, Corey D. Myosin-VIIb, a Novel Unconventional Myosin, Is a Constituent of Microvilli in Transporting Epithelia. Genomics 2001, 72: 285-296. PMID: 11401444, DOI: 10.1006/geno.2000.6456.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBiological TransportBlotting, NorthernBlotting, WesternChromosome MappingCloning, MolecularDNA, ComplementaryEpitheliumExonsFemaleGenesImmunohistochemistryIntestinesIntronsKidneyMiceMice, Inbred BALB CMicrovilliMolecular Sequence DataMyosinsPhylogenyProtein IsoformsRNA, MessengerSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidTissue Distribution
1996
Molecular Cloning and Domain Structure of Human Myosin-VIIa, the Gene Product Defective in Usher Syndrome 1B
Chen Z, Hasson T, Kelley P, Schwender B, Schwartz M, Ramakrishnan M, Kimberling W, Mooseker M, Corey D. Molecular Cloning and Domain Structure of Human Myosin-VIIa, the Gene Product Defective in Usher Syndrome 1B. Genomics 1996, 36: 440-448. PMID: 8884267, DOI: 10.1006/geno.1996.0489.Peer-Reviewed Original ResearchConceptsUsher syndrome 1BIntestinal epithelium cell lineProgressive retinal degenerationEpithelium cell lineVestibular functionMyosin VIIaPigment epitheliumRetinal degenerationInner earReceptor cellsRT-PCRBand 4.1 familyRestricted expressionShort formCell linesMembrane-associated portionHuman myosin VIIaMolecular cloningLong transcriptsTestisShort transcriptsUnconventional myosinLong repeatsHigh abundanceAmino acids
1995
Unconventional Myosins
Mooseker M, Cheney R. Unconventional Myosins. Annual Review Of Cell And Developmental Biology 1995, 11: 633-675. PMID: 8689571, DOI: 10.1146/annurev.cb.11.110195.003221.Peer-Reviewed Original ResearchMeSH KeywordsAcanthamoebaAmino Acid SequenceAnimalsArabidopsisDeafnessDrosophilaHumansMiceMolecular Sequence DataMyosinsPhylogenySaccharomyces cerevisiaeSequence Homology, Amino AcidSwineConceptsUnconventional myosinExpression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Hasson T, Heintzelman M, Santos-Sacchi J, Corey D, Mooseker M. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 9815-9819. PMID: 7568224, PMCID: PMC40893, DOI: 10.1073/pnas.92.21.9815.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAmino Acid SequenceAnimalsAntibody SpecificityBlindnessCochleaDeafnessDyneinsFluorescent Antibody TechniqueGuinea PigsHearing Loss, SensorineuralHumansImmunoblottingMolecular Sequence DataMyosin VIIaMyosinsRatsRetinaRetinitis PigmentosaSequence Homology, Amino AcidSwineSyndromeTissue DistributionConceptsHair cellsMyosin VIIa expressionEpithelial cellsMyosin VIIaCochlear hair cellsMyosin VIIa functionOuter hair cellsUsher syndrome type 1BMyosin VIIA geneVestibular dysfunctionCell-specific localizationCongenital deafnessRetinitis pigmentosaUsher syndromeType 1bType 1B.Normal functionApical stereociliaVIIaDeafnessDisease phenotypeCochleaInherited diseaseRetinaShaker-1TEDS rule: A molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain head
Bement W, Mooseker M. TEDS rule: A molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain head. Cytoskeleton 1995, 31: 87-92. PMID: 7553910, DOI: 10.1002/cm.970310202.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsHumansMolecular Sequence DataMyosin Heavy ChainsMyosinsPhosphorylationSequence Homology, Amino Acid
1994
Cloning and mRNA Expression of Human Unconventional Myosin-IC A Homologue of Amoeboid Myosins-I With a Single IQ Motif and an SH3 Domain
Bement W, Wirth J, Mooseker M. Cloning and mRNA Expression of Human Unconventional Myosin-IC A Homologue of Amoeboid Myosins-I With a Single IQ Motif and an SH3 Domain. Journal Of Molecular Biology 1994, 243: 356-363. PMID: 7932763, DOI: 10.1006/jmbi.1994.1662.Peer-Reviewed Original ResearchMeSH KeywordsAcanthamoebaAmino Acid SequenceAnimalsBase SequenceCloning, MolecularDictyosteliumHumansMolecular Sequence DataMyosinsRNA, MessengerSequence Homology, Amino AcidConceptsSrc homology 3 domainSingle IQ motifIQ motifComplete deduced amino acid sequenceDeduced amino acid sequenceSingle open reading frameC-terminal tailOpen reading frameATP-binding siteAmino acid sequenceMembrane-binding sitesMultiple sequence alignmentNorthern blot analysisSH3 domainCDNA clonesReading frameAcid sequenceSequence alignmentMyosin ICIdentification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.
Bement W, Hasson T, Wirth J, Cheney R, Mooseker M. Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6549-6553. PMID: 8022818, PMCID: PMC44240, DOI: 10.1073/pnas.91.14.6549.Peer-Reviewed Original ResearchThe Molecular Cloning and Characterization of Drosophila melanogaster Myosin-IA and Myosin-IB
Morgan N, Skovronsky D, Artavanis-Tsakonas S, Mooseker M. The Molecular Cloning and Characterization of Drosophila melanogaster Myosin-IA and Myosin-IB. Journal Of Molecular Biology 1994, 239: 347-356. PMID: 8201616, DOI: 10.1006/jmbi.1994.1376.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCloning, MolecularConsensus SequenceConserved SequenceDrosophila melanogasterGenes, InsectLarvaMolecular Sequence DataMyosinsProtein Structure, TertiaryRNA, MessengerSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidTranscription, GeneticConceptsDeduced amino acid sequenceKilobase cDNA cloneAmino acid sequenceMyosin IBCDNA clonesIQ motifGene productsAcid sequenceMyosin I familyDrosophila cDNA libraryPrimary sequence analysisMyosin IANorthern blot analysisVertebrate homologsEmbryonic libraryDrosophila melanogasterMolecular cloningSequence comparisonNovel myosinCDNA libraryTail domainHead libraryUnique tailDegenerate primersUnconventional myosinIdentification of a Divergent Actin-related Protein in Drosophila
Frankel S, Heintzelman M, Artavanis-Tsakonas S, Mooseker M. Identification of a Divergent Actin-related Protein in Drosophila. Journal Of Molecular Biology 1994, 235: 1351-1356. PMID: 8308899, DOI: 10.1006/jmbi.1994.1090.Peer-Reviewed Original ResearchConceptsActin-related proteinsAmino acid identityPrimary sequence homologyDivergent actinConventional actinPolytene chromosomesEarly embryogenesisAcid identityX chromosomeSequence homologyGenomic DNAOverall divergenceSequence insertionNew isotypeActinDrosophilaProteinEmbryogenesisChromosomesHomologyGenesStages of developmentTranscriptsUnique locationLater stages
1993
An in vitro model for the analysis of intestinal brush border assembly. II. Changes in expression and localization of brush border proteins during cell contact-induced brush border assembly in Caco-2BBe cells.
Peterson M, Bement W, Mooseker M. An in vitro model for the analysis of intestinal brush border assembly. II. Changes in expression and localization of brush border proteins during cell contact-induced brush border assembly in Caco-2BBe cells. Journal Of Cell Science 1993, 105 ( Pt 2): 461-72. PMID: 8408277, DOI: 10.1242/jcs.105.2.461.Peer-Reviewed Original ResearchActinsAdenocarcinomaAmino Acid SequenceAnimalsBiomarkersBirdsCarrier ProteinsCattleCell CommunicationCell PolarityClone CellsColonic NeoplasmsCytoskeletonGene Expression Regulation, NeoplasticHumansIntestinal MucosaMicrofilament ProteinsMicrovilliMolecular Sequence DataMyosinsNeoplasm ProteinsOligo-1,6-GlucosidaseSequence AlignmentSequence Homology, Amino AcidSpecies SpecificitySucraseTumor Cells, CulturedCloning of a Secretory Gelsolin from Drosophila melanogaster
Heintzelman M, Frankel S, Artavanis-Tsakonas S, Mooseker M. Cloning of a Secretory Gelsolin from Drosophila melanogaster. Journal Of Molecular Biology 1993, 230: 709-716. PMID: 8386771, DOI: 10.1006/jmbi.1993.1191.Peer-Reviewed Original ResearchConceptsSecretory gelsolinAcid sequenceThird instar Drosophila larvaeDeduced amino acid sequenceFull-length complementary DNAInstar Drosophila larvaeClass of proteinsActin-binding proteinsAmino acid sequenceAmino acid residuesGelsolin sequenceThird chromosomeDrosophila melanogasterGelsolin familyCytoplasmic proteinsSignal peptideSingle geneDrosophila larvaeRepeat structureActin filamentsMonomeric actinAcid residuesBarbed endsPrimary structureNorthern blot