2024
A machine learning framework to adjust for learning effects in medical device safety evaluation
Koola J, Ramesh K, Mao J, Ahn M, Davis S, Govindarajulu U, Perkins A, Westerman D, Ssemaganda H, Speroff T, Ohno-Machado L, Ramsay C, Sedrakyan A, Resnic F, Matheny M. A machine learning framework to adjust for learning effects in medical device safety evaluation. Journal Of The American Medical Informatics Association 2024, ocae273. PMID: 39471493, DOI: 10.1093/jamia/ocae273.Peer-Reviewed Original ResearchMachine learning frameworkSynthetic datasetsLearning frameworkMachine learningCapacity of MLLearning effectFeature correlationDepartment of Veterans AffairsSynthetic dataData generationAbsence of learning effectsTraditional statistical methodsML methodsSuperior performanceDatasetSafety signal detectionSignal detectionDevice signalsVeterans AffairsTime-varying covariatesLearningMachinePhysician experienceLimitations of traditional statistical methodsMedical device post-market surveillance
2018
A Scalable Privacy-preserving Data Generation Methodology for Exploratory Analysis.
Vaidya J, Shafiq B, Asani M, Adam N, Jiang X, Ohno-Machado L. A Scalable Privacy-preserving Data Generation Methodology for Exploratory Analysis. AMIA Annual Symposium Proceedings 2018, 2017: 1695-1704. PMID: 29854240, PMCID: PMC5977652.Peer-Reviewed Original ResearchConceptsPrivacy-preserving approachData management systemBig dataBiomedical datasetsClassification taskBiomedical dataContext of regressionManagement systemSynthetic dataGeneration methodologyEssential problemResearch tasksAdditional datasetsDatasetTaskSignificant effortsDirect accessFirstorder approximationDataParticular typeAccessPrecision medicine
2012
Privacy-preserving heterogeneous health data sharing
Mohammed N, Jiang X, Chen R, Fung B, Ohno-Machado L. Privacy-preserving heterogeneous health data sharing. Journal Of The American Medical Informatics Association 2012, 20: 462-469. PMID: 23242630, PMCID: PMC3628047, DOI: 10.1136/amiajnl-2012-001027.Peer-Reviewed Original ResearchConceptsSet-valued dataDifferential privacyNoise additionPrivacy-preserving mannerAdversary's background knowledgeStrong privacy guaranteesBackground knowledgeHealth data sharingPrivacy modelPrivacy guaranteesSensitive dataData sharingHealthcare dataPrivate mannerAlgorithm designPrivacyRaw dataSynthetic dataAlgorithmHealth dataProbabilistic wayDiscriminative analysisExperimental resultsUseful informationClassification analysis