2023
Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction
Colliard K, Nurko S, Flores A, Rodriguez L. Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 327-331. PMID: 37229777, DOI: 10.1097/mpg.0000000000003841.Peer-Reviewed Original ResearchConceptsAntroduodenal manometryDefecation disordersPostprandial responseGroup BChronic Intestinal Pseudo-ObstructionIntestinal Pseudo-ObstructionNormal postprandial responseModerate agreementSmall bowel motilityLogistic regression analysisOstomy closurePseudo-ObstructionBowel motilityRetrospective reviewIleal motilityIndication groupGroup AClinical utilityYounger agePatientsMotility patternsPhase IIIMotor complexDisordersManometryClinical utility of colonic low‐amplitude propagating contractions in children with functional constipation
Colliard K, Patel D, Nurko S, Rodriguez L. Clinical utility of colonic low‐amplitude propagating contractions in children with functional constipation. Neurogastroenterology & Motility 2023, 35: e14543. PMID: 37096634, DOI: 10.1111/nmo.14543.Peer-Reviewed Original ResearchConceptsFunctional constipationLogistic regressionClinical utilityPediatric functional constipationConstipation groupRetrospective reviewColonic enemaClinical significanceLAPCConstipationNeuromuscular integrityLarger studyPatientsOutcomesChildrenAssociationContractionHigher proportionHAPCsGroupRegressionIleostomyEnema
2022
Diverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndicationsEvaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum
Rodriguez L, Morley‐Fletcher A, Winter H, Timothy B. Evaluation of Gastroesophageal Reflux Disease in Children on the Autism Spectrum. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 450-454. PMID: 35830732, DOI: 10.1097/mpg.0000000000003561.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseSymptom correlationBravo wirelessReflux diseaseEvaluation of GERDMedian reflux indexNon-ASD childrenSignificant side effectsASD childrenNormal esophageal mucosaAutism spectrum disorderSelf-injurious behaviorChest painReflux indexGER episodesGER symptomsMale predominanceAbnormal studiesPatient populationEsophageal mucosaSupine positionLarge cohortSide effectsBehavioral symptomsStudy duration
2021
Upper Gastrointestinal Functional and Motility Disorders in Children
Miller J, Khlevner J, Rodriguez L. Upper Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1237-1253. PMID: 34736587, DOI: 10.1016/j.pcl.2021.07.009.Peer-Reviewed Original ResearchConceptsMotility disordersNew diagnostic studiesUpper gastrointestinal tractAbdominal painChest painMechanisms of diseaseClinical presentationMotor functionGastrointestinal tractGastrointestinal physiologyTherapeutic interventionsDiagnostic studiesDisordersNormal functionPainChildrenDysphagiaNauseaVomitingDysfunctionEsophagusSymptomsStomachDiseaseDiagnosisLower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestineCan Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies?
Arbizu RA, Amicangelo M, Rodriguez L, Nurko S. Can Propofol Be Used to Assess the Presence of the Rectoanal Inhibitory Reflex During Anorectal Manometry Studies? Journal Of Pediatric Gastroenterology And Nutrition 2021, 74: 33-37. PMID: 34478251, DOI: 10.1097/mpg.0000000000003283.Peer-Reviewed Original ResearchConceptsIntra-anal pressuresRectoanal inhibitory reflexAnorectal manometryInhibitory reflexAbsent rectoanal inhibitory reflexInternal anal sphincter relaxationNormal rectoanal inhibitory reflexAnal sphincter relaxationAnorectal manometry studyBalloon distentionIAS relaxationSpinal neuropathyIntractable constipationObstructive symptomsSphincter relaxationProspective studyAnesthesia inductionManometry studiesPatientsPropofolDisease repairLatency timeConstipationAnesthesiaReflexMelanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation
Chen JJ, Kitzia Colliard RN, Nurko S, Rodriguez L. Melanosis Coli Is Not Associated with Colonic Dysmotility Nor Severity of Pediatric Functional Constipation. Digestive Diseases And Sciences 2021, 67: 3922-3928. PMID: 34379221, DOI: 10.1007/s10620-021-07191-z.Peer-Reviewed Original ResearchConceptsPediatric functional constipationMelanosis coliFunctional constipationColonic manometryColonic motilityMarker of severityTreatment of constipationRate of surgeryColonic dysmotilityColonic biopsiesMedian agePediatric patientsManometry resultsMedication historyMethodsProspective studyPatient groupResultsA totalSurgical historyPathologic resultsConstipationPatientsCatheter positionDemographic dataSubsequent needSignificant differences
2020
Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders
Rodriguez L, Heinz N, Colliard K, Amicangelo M, Nurko S. Diagnostic and clinical utility of the wireless motility capsule in children: A study in patients with functional gastrointestinal disorders. Neurogastroenterology & Motility 2020, 33: e14032. PMID: 33184926, DOI: 10.1111/nmo.14032.Peer-Reviewed Original ResearchConceptsWireless motility capsuleColon transitGastrointestinal symptomsCapsule retentionMotility capsuleLower gastrointestinal symptomsRadiopaque marker studiesFunctional gastrointestinal symptomsFunctional gastrointestinal disordersNuclear medicine gastricGastrointestinal motilityGastrointestinal disordersTransit abnormalitiesClinical utilityGastric transitSymptomsLarger studyPatientsInterpretation agreementMarker studiesMotility parametersStudy interpretationCROMSignificant correlationChildrenEvaluation of Fecal Incontinence in Pediatric Functional Constipation
Morera C, Nurko S, Rodriguez L. Evaluation of Fecal Incontinence in Pediatric Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2020, 72: 361-365. PMID: 33560756, DOI: 10.1097/mpg.0000000000002978.Peer-Reviewed Original ResearchConceptsPediatric functional constipationFecal incontinenceFunctional constipationColonic manometryMedian anal resting pressureAnal resting pressureMore patientsResting pressureAbnormal studiesConventional therapyMale genderTreatment outcomesClinical dataConstipationNormal studiesTherapy responseMeal responseIncontinencePatientsMultivariate analysisMotility studiesTherapyNormal armLow responseManometryLong‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy
Bonilla S, Nurko S, Rodriguez L. Long‐term Use of Bisacodyl in Pediatric Functional Constipation Refractory to Conventional Therapy. Journal Of Pediatric Gastroenterology And Nutrition 2020, 71: 288-291. PMID: 32459741, DOI: 10.1097/mpg.0000000000002795.Peer-Reviewed Original ResearchConceptsConventional therapyLong-term usePediatric constipationFunctional constipationSide effectsTertiary care children's hospitalFrequency of BMPediatric functional constipationBowel movement frequencyLong-term followLong-term treatmentMedian doseRescue therapyMedian durationStandard therapyOsmotic laxativesRetrospective reviewPediatric populationChildren's HospitalStimulant laxativesMedian numberConstipationPatientsTreatment durationFavorable responseUtility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders
Rodriguez L, Heinz N, Nurko S. Utility of Colon Manometry in Guiding Therapy and Predicting Need for Surgery in Children With Defecation Disorders. Journal Of Pediatric Gastroenterology And Nutrition 2020, 70: 232-237. PMID: 31978023, DOI: 10.1097/mpg.0000000000002504.Peer-Reviewed Original ResearchConceptsColon manometryChange of therapyGastrocolonic responseHigh response rateDefecation disordersResponse rateMedical interventionsLogistic regression analysisPresence/numberPediatric constipationFecal incontinenceSuccessful medical interventionDefecation problemsRetrospective reviewPredicting NeedPostsurgical evaluationSurgical interventionStimulant laxativesStudy indicationSurgeryTherapyFirst interventionInterventionConstipationManometry
2018
Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Same day versus next day antroduodenal manometry results in children with upper gastrointestinal symptoms: A prospective study. Neurogastroenterology & Motility 2018, 31: e13521. PMID: 30537362, DOI: 10.1111/nmo.13521.Peer-Reviewed Original ResearchConceptsSmall bowel motility indexDay 1Day 2Motility indexAbnormal studiesCatheter placementNormal studiesPhase IIIStudy interpretationChallenge phaseUpper gastrointestinal symptomsProportion of patientsGastrointestinal symptomsManometry resultsPostprandial responseProspective studyManometry parametersPatientsStudy parametersMotor complexSame dayAntrumDaysAnesthesiaCatheterPrimary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC)
Graham CD, Rodriguez L, Flores A, Nurko S, Buchmiller TL. Primary placement of a skin-level Cecostomy Tube for Antegrade Colonic Enema Administration Using a Modification of the Laparoscopic-Assisted Percutaneous Endoscopic Cecostomy (LAPEC). Journal Of Pediatric Surgery 2018, 54: 486-490. PMID: 30409477, DOI: 10.1016/j.jpedsurg.2018.09.013.Peer-Reviewed Original ResearchConceptsSkin-level deviceTube placementPrimary placementCecostomy tubeHigher BMIEnema administrationExact testSingle-institution retrospective reviewSuspension suturesAntegrade enema administrationCecostomy tube placementPercutaneous endoscopic cecostomyPEG tube placementMajority of patientsCase series studyAntegrade colonic enemaPercutaneous needle punctureSuccessful tube placementFisher's exact testBowel managementFecal incontinenceSevere constipationPatient characteristicsPEG placementSite infectionThoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study
Duggan EM, Nurko S, Smithers CJ, Rodriguez L, Fox VL, Fishman SJ. Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. Journal Of Pediatric Surgery 2018, 54: 572-576. PMID: 30121126, DOI: 10.1016/j.jpedsurg.2018.07.013.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyThoracoscopic esophagomyotomyPneumatic dilationCohort studyPediatric populationLength of stayInitial symptom reliefInvasive esophagomyotomyPreoperative dilationPostoperative painRecurrent symptomsMucosal injuryLaparoscopic approachSymptom reliefMedian lengthStandard treatmentEndoscopic guidanceOpen procedureEsophagomyotomyRare diseasePatientsAchalasiaEffective procedureDilationFundoplication
2017
Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation
Arbizu RA, Nurko S, Heinz N, Amicangelo M, Rodriguez L. Prospective evaluation of same day versus next day colon manometry results in children with medical refractory constipation. Neurogastroenterology & Motility 2017, 29 PMID: 28317231, PMCID: PMC5466533, DOI: 10.1111/nmo.13050.Peer-Reviewed Original ResearchConceptsDay 1Day 2Normal studiesAbnormal studiesProportion of patientsSame dayStudy interpretationColon manometryGastrocolonic responseRefractory constipationProspective evaluationManometry parametersMotility indexPatientsChallenge phaseAbstractTextAnesthesiaCatheterStudy parametersColonoscopyDaysConstipationHAPCsManometryStudy
2016
Pediatric rumination subtypes: A study using high‐resolution esophageal manometry with impedance
Rosen R, Rodriguez L, Nurko S. Pediatric rumination subtypes: A study using high‐resolution esophageal manometry with impedance. Neurogastroenterology & Motility 2016, 29 PMID: 28002887, PMCID: PMC5393952, DOI: 10.1111/nmo.12998.Peer-Reviewed Original ResearchUtility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction
Ambartsumyan L, Flores A, Nurko S, Rodriguez L. Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Pediatric Drugs 2016, 18: 387-392. PMID: 27520652, DOI: 10.1007/s40272-016-0189-x.Peer-Reviewed Original ResearchConceptsOctreotide responseEnteral toleranceAntroduodenal manometryChronic Intestinal Pseudo-ObstructionEfficacy of octreotideIntestinal phase IIIIntestinal Pseudo-ObstructionPresence of ileostomyTPN-dependent childrenTertiary care centerTotal parenteral nutritionMethodsThe study populationLimited effective therapiesHigher median increasePseudo-ObstructionParenteral nutritionEnteral feedsHigh morbidityProspective studyResultsA totalCare centerEffective therapyChallenging disorderAllergic reactionsStudy population
2015
Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements
Rodriguez L, Morley-Fletcher A, Souza A, Rosengaus L, Nurko S. Effect of anesthesia on gastroesophageal reflux in children: a study using BRAVO wireless pH study measurements. Neurogastroenterology & Motility 2015, 27: 1553-1558. PMID: 26264213, PMCID: PMC4624481, DOI: 10.1111/nmo.12652.Peer-Reviewed Original ResearchConceptsEffects of anesthesiaGastroesophageal refluxBravo wirelessStudy interpretationAnesthesia effectProportion of studiesRole of anesthesiaGER parametersCapsule placementAnesthesiaCutoff valueStudy durationAbstractTextSignificant increaseChildrenRefluxSignificant changesStudy measurementsDaysHoursBlock timePatientsStudyProportionHigh-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children
Rommel N, Omari TI, Selleslagh M, Kritas S, Cock C, Rosan R, Rodriguez L, Nurko S. High-resolution manometry combined with impedance measurements discriminates the cause of dysphagia in children. European Journal Of Pediatrics 2015, 174: 1629-1637. PMID: 26105773, DOI: 10.1007/s00431-015-2582-9.Peer-Reviewed Original ResearchConceptsPressure-flow analysisPressure-flow indexGastroesophageal reflux diseaseCause of dysphagiaWeak peristalsisPost-fundoplication dysphagiaHigh-resolution manometryPediatric patientsEsophageal dysfunctionDysphagia symptomsEndoscopic therapyNormal peristalsisOptimal treatmentEsophageal functionClinical practiceTrachea-esophageal fistulaDifferentiation of patientsNon-obstructive dysphagiaPressure flow parametersPediatric clinical practicePressure-flow metricsAdult patientsReflux diseaseEsophageal motilityEsophageal bolus transport