2023
Pediatric Neurogastroenterology and Motility Disorders What Role Does Endoscopy Play?
Khlevner J, Patel D, Rodriguez L. Pediatric Neurogastroenterology and Motility Disorders What Role Does Endoscopy Play? Gastrointestinal Endoscopy Clinics Of North America 2023, 33: 379-399. PMID: 36948752, DOI: 10.1016/j.giec.2022.10.004.Peer-Reviewed Original ResearchConceptsPaediatric neurogastroenterologyMotility disordersOral endoscopic myotomyTherapeutic gastrointestinal endoscopyIncisional therapySmall bowelEndoscopic myotomyAnorectal disordersGastrointestinal endoscopyDiagnostic endoscopyFunctional lumenAxis interactionTherapeutic landscapeNovel modalityDisordersNeurogastroenterologyEndoscopyBowelMyotomyEsophagealColonicTherapy
2018
Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study
Duggan EM, Nurko S, Smithers CJ, Rodriguez L, Fox VL, Fishman SJ. Thoracoscopic esophagomyotomy for achalasia in the pediatric population: A retrospective cohort study. Journal Of Pediatric Surgery 2018, 54: 572-576. PMID: 30121126, DOI: 10.1016/j.jpedsurg.2018.07.013.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyThoracoscopic esophagomyotomyPneumatic dilationCohort studyPediatric populationLength of stayInitial symptom reliefInvasive esophagomyotomyPreoperative dilationPostoperative painRecurrent symptomsMucosal injuryLaparoscopic approachSymptom reliefMedian lengthStandard treatmentEndoscopic guidanceOpen procedureEsophagomyotomyRare diseasePatientsAchalasiaEffective procedureDilationFundoplication
2012
Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children
Rodriguez L, Irani K, Jiang H, Goldstein AM. Clinical Presentation, Response to Therapy, and Outcome of Gastroparesis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2012, 55: 185-190. PMID: 22228004, DOI: 10.1097/mpg.0b013e318248ed3f.Peer-Reviewed Original ResearchConceptsPediatric gastroparesisPostviral gastroparesisPromotility therapySymptom resolutionClinical featuresMitochondrial dysfunctionYounger ageOutcomes of gastroparesisMore vomitingPromotility drugsAbdominal painClinical presentationMedian timeRetrospective reviewMale sexMean ageEffective therapyGastroparesisVariable symptomatologyMultivariate analysisTherapySymptomsMonthsLonger durationOverall rateEndoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study
Rodriguez L, Rosen R, Manfredi M, Nurko S. Endoscopic intrapyloric injection of botulinum toxin A in the treatment of children with gastroparesis: a retrospective, open-label study. Gastrointestinal Endoscopy 2012, 75: 302-309. PMID: 22248598, PMCID: PMC3260460, DOI: 10.1016/j.gie.2011.09.042.Peer-Reviewed Original ResearchConceptsOpen-label studyBotulinum toxin APredictive factorsToxin ASingle tertiary care centerLong-term clinical outcomesRefractory gastroparesis symptomsSymptoms of gastroparesisPlacebo-controlled trialTertiary care centerManagement of childrenSingle case reportsTreatment of childrenGastroparesis refractoryGastroparesis symptomsIntrapyloric injectionReported exacerbationsSpastic disordersClinical improvementMedian durationOlder patientsBotulinum injectionMale patientsMedical therapyRetrospective review
2010
Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation
Christison-Lagay ER, Rodriguez L, Kurtz M, St. Pierre K, Doody DP, Goldstein AM. Antegrade colonic enemas and intestinal diversion are highly effective in the management of children with intractable constipation. Journal Of Pediatric Surgery 2010, 45: 213-219. PMID: 20105606, DOI: 10.1016/j.jpedsurg.2009.10.034.Peer-Reviewed Original ResearchConceptsAntegrade continence enemaIntractable constipationSatisfactory outcomeContinence enemaIntestinal continuityRetrospective reviewSurgical approachPredictors of successColonic manometry studiesPassage of stoolPrimary colonic resectionManagement of childrenOptimal surgical approachAntegrade colonic enemaInitial therapyAbdominal distensionIdiopathic constipationPrimary resectionColonic resectionAdditional surgeryColonic manometryMedical therapyPediatric patientsACE procedureColonic enema
2008
Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction
Irani K, Rodriguez L, Doody DP, Goldstein AM. Botulinum toxin for the treatment of chronic constipation in children with internal anal sphincter dysfunction. Pediatric Surgery International 2008, 24: 779-783. PMID: 18443801, DOI: 10.1007/s00383-008-2171-3.Peer-Reviewed Original ResearchConceptsInternal anal sphincter dysfunctionAnal sphincter dysfunctionIntrasphincteric injectionSphincter dysfunctionIntractable constipationPediatric patientsBotulinum toxinIAS dysfunctionAbnormal anorectal manometryRectoanal inhibitory reflexTreatment of constipationDuration of effectChronic constipationPostoperative incontinenceRefractory constipationInhibitory reflexAnorectal manometryResting pressureRetrospective reviewBotox injectionHirschsprung's diseaseConstipationEffective treatmentPatientsDysfunction