2020
RPE Polarity and Barrier Function
Rizzolo L. RPE Polarity and Barrier Function. 2020, 19-45. DOI: 10.1007/978-3-030-28384-1_2.ChaptersCell polarityEpithelial cell polarityPlasma membrane domainsTight junctionsBasolateral plasma membraneRPE polarityCellular processesMembrane domainsPlasma membraneMembrane transportersMembrane transportNeighboring cellsRPE phenotypeSemi-selective barrierProteinBarrier functionJunction proteinsRPE functionParacellular spaceOuter blood-retinal barrierVisual cycleTight junction proteinsTransepithelial electrical resistanceAsymmetric distributionDynamic interplay
2013
Engineering a Blood-Retinal Barrier With Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Transcriptome and Functional Analysis
Peng S, Gan G, Qiu C, Zhong M, An H, Adelman RA, Rizzolo LJ. Engineering a Blood-Retinal Barrier With Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Transcriptome and Functional Analysis. Stem Cells Translational Medicine 2013, 2: 534-544. PMID: 23734062, PMCID: PMC3697821, DOI: 10.5966/sctm.2012-0134.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumBlood-retinal barrierHuman retinal pigment epitheliumPigment epitheliumHuman fetal retinal pigment epitheliumOuter blood-retinal barrierTight junctionsFetal retinal pigment epitheliumEmbryonic stem cell-derived retinal pigment epitheliumAdult retinal pigment epitheliumQuantitative reverse transcription polymerase chain reactionMaturation of hESCReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionHuman embryonic stem cell-derived retinal pigment epitheliumStem cell-derived retinal pigment epitheliumRPE replacement therapyPanel of genesReplacement therapyAnimal modelsHuman embryonic stem cellsRetinal degenerationRPE functionSerum-free mediumHuman retina