2020
Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms
Ranjan K. Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms. Gastrointestinal Disorders 2020, 2: 24. DOI: 10.3390/gidisord2030024.Peer-Reviewed Original ResearchInflammatory bowel diseaseIntestinal epithelial cellsIntestinal immune homeostasisBowel diseaseImmune homeostasisMyeloid cellsPeripheral myeloid cellsChronic inflammatory conditionsGut-resident microbesUnfolded protein responseInflammatory conditionsIntestinal homeostasisSusceptible individualsHomeostatic environmentChronic stressIntracellular mechanismsOxidative stressEpithelial cellsEndoplasmic reticulumDiseaseHomeostasisResident microbesProtein responseCellsCellular stress
2016
Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress
Ranjan K, Pathak C. Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress. Journal Of Cellular Biochemistry 2016, 117: 1757-1768. PMID: 26682748, DOI: 10.1002/jcb.25474.Peer-Reviewed Original ResearchConceptsAutophagic stressDependent ubiquitinationBeclin-1Bcl-2Cell deathExpression of cFLIPLCo-immunoprecipitation analysisRegulation of autophagyHEK 293T cellsDifferent physiological processesAnti-apoptotic proteinsCellular homeostasisCellular stressEctopic expressionKnockdown cellsJNK1 activationCanonical interactionsProtein HMGB1Physiological processesBasal interactionCFLIPLSelective knockdownUbiquitinationAutophagyH2 O2