2021
Progression of depression and anxiety symptoms in pregnancies conceived by assisted reproductive technology in the United States
Simoni MK, Gilstad-Hayden K, Naqvi SH, Pal L, Yonkers KA. Progression of depression and anxiety symptoms in pregnancies conceived by assisted reproductive technology in the United States. Journal Of Psychosomatic Obstetrics & Gynecology 2021, 43: 214-223. PMID: 34472405, PMCID: PMC10116357, DOI: 10.1080/0167482x.2021.1971193.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyDepressionFemaleHumansPregnancyProspective StudiesPsychiatric Status Rating ScalesReproductive Techniques, AssistedUnited StatesConceptsAssisted-reproductive technologyEdinburgh Postnatal Depression ScalePlanned pregnanciesPostnatal Depression ScaleGestational time periodsART pregnanciesProspective cohortPregnant womenWeeks postpartumGeneralized Estimating EquationsObstetrical practiceDepression ScaleDepressive symptomsPregnancyBlue studiesSecondary analysisConception groupMental healthAnxiety subscaleAnxiety symptomsWomenGroup changesSymptomsPrevalenceWeeks
2019
The Most Valuable Resource Is Time: Insights From a Novel National Program to Improve Retention of Physician-Scientists With Caregiving Responsibilities.
Jones RD, Miller J, Vitous CA, Krenz C, Brady KT, Brown AJ, Daumit GL, Drake AF, Fraser VJ, Hartmann KE, Hochman JS, Girdler S, Libby AM, Mangurian C, Regensteiner JG, Yonkers K, Jagsi R. The Most Valuable Resource Is Time: Insights From a Novel National Program to Improve Retention of Physician-Scientists With Caregiving Responsibilities. Academic Medicine 2019, 94: 1746-1756. PMID: 31348060, DOI: 10.1097/acm.0000000000002903.Peer-Reviewed Original Research
2016
Are pregnancy planning and pregnancy timing associated with maternal psychiatric illness, psychological distress and support during pregnancy?
Gariepy AM, Lundsberg LS, Miller D, Stanwood NL, Yonkers KA. Are pregnancy planning and pregnancy timing associated with maternal psychiatric illness, psychological distress and support during pregnancy? Journal Of Affective Disorders 2016, 205: 87-94. PMID: 27423065, PMCID: PMC5048515, DOI: 10.1016/j.jad.2016.06.058.Peer-Reviewed Original ResearchConceptsMajor depressive episodeCohen's Perceived Stress ScaleMaternal psychiatric illnessPregnancy planningPsychiatric illnessHighest quartilePsychological distressPregnancy timingComposite International Diagnostic InterviewMultivariable logistic regressionImpact of depressionGeneral anxiety disorderLow social supportSocial Support InventoryProspective cohortPreterm birthPregnant womenDepressive episodeUnplanned pregnancyPerceived Stress ScalePregnancyPsychiatric diagnosisPsychiatric conditionsSecondary analysisDiagnostic InterviewEarly Childhood Adversity and Pregnancy Outcomes
Smith MV, Gotman N, Yonkers KA. Early Childhood Adversity and Pregnancy Outcomes. Maternal And Child Health Journal 2016, 20: 790-798. PMID: 26762511, PMCID: PMC4849279, DOI: 10.1007/s10995-015-1909-5.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesGestational agePregnancy outcomesBirth weightConclusions ACEsComposite International Diagnostic InterviewEarly Trauma Inventory Self Report-Short FormMaternal reproductive healthShorter gestational ageAdditional adverse childhood experienceDelivery of offspringPregnant womenHealth habitsPsychiatric illnessPsychiatric diagnosisReproductive healthDiagnostic InterviewChildhood adversityShort formMultiple mediatorsAgeChildhood experiencesMediatorsMethods ExposureOutcomes
2015
Are pregnancy planning and timing associated with preterm or small for gestational age births?
Gariepy AM, Lundsberg LS, Stolar M, Stanwood NL, Yonkers KA. Are pregnancy planning and timing associated with preterm or small for gestational age births? Fertility And Sterility 2015, 104: 1484-1492. PMID: 26364840, PMCID: PMC4663160, DOI: 10.1016/j.fertnstert.2015.08.012.Peer-Reviewed Original ResearchConceptsGestational-age birthsPregnancy planningAge birthGestational ageSignificant associationGestational age infantsProspective cohort studyMedical record abstractionHigh-risk populationMultiple confounding factorsMaternal demographicsCohort studyPreterm birthSingleton pregnanciesRecord abstractionPregnant womenAge infantsRisk factorsPregnancy timingHigh prevalenceLarge cohortPretermMAIN OUTCOMEMedical conditionsOutcome dataPerinatal substance use: A prospective evaluation of abstinence and relapse
Forray A, Merry B, Lin H, Ruger JP, Yonkers KA. Perinatal substance use: A prospective evaluation of abstinence and relapse. Drug And Alcohol Dependence 2015, 150: 147-155. PMID: 25772437, PMCID: PMC4387084, DOI: 10.1016/j.drugalcdep.2015.02.027.Peer-Reviewed Original ResearchConceptsRates of abstinenceMean daysSubstance useMultivariate Cox modelLittle prospective dataPostpartum relapseRelapse postpartumAbstinence ratesProspective evaluationNicotine cigarettesProspective dataCox modelPregnancyRelapseCigarettesAbstinenceToxicology testingCocaineWomenPsychological treatmentLast monthPostpartumMarijuanaSpecific substancesDays
2014
Clinical Correlates of Prescription Opioid Analgesic Use in Pregnancy
Smith MV, Costello D, Yonkers KA. Clinical Correlates of Prescription Opioid Analgesic Use in Pregnancy. Maternal And Child Health Journal 2014, 19: 548-556. PMID: 24951127, PMCID: PMC4272915, DOI: 10.1007/s10995-014-1536-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnxiety DisordersComorbidityDepressive Disorder, MajorDrug PrescriptionsFemaleHumansIllicit DrugsOpioid-Related DisordersPainPregnancyPrevalenceProspective StudiesRegression AnalysisRisk FactorsStress Disorders, Post-TraumaticSurveys and QuestionnairesUnited StatesYoung AdultConceptsNon-opioid usersPregnant womenOpioid analgesicsClinical correlatesPrescription opioid analgesic useComposite International Diagnostic InterviewAnxiety disordersOpioid analgesic useProspective cohort studyUse of opioidsMajor depressive disorderPercent of womenPost-traumatic stress disorderAnalgesic useCohort studyOpioid useMedication useThird trimesterPsychiatric comorbidityDepressive disorderSmoking cigarettesOpioid addictionAmerican CollegeDiagnostic criteriaPregnancy
2013
Perinatal smoking and depression in women with concurrent substance use
Forray A, Gotman N, Kershaw T, Yonkers KA. Perinatal smoking and depression in women with concurrent substance use. Addictive Behaviors 2013, 39: 749-756. PMID: 24447885, PMCID: PMC3944019, DOI: 10.1016/j.addbeh.2013.12.008.Peer-Reviewed Original ResearchConceptsPregnant womenConcurrent substance useSubstance usePre-pregnancy smokersSignificant depressive symptomsWeeks of pregnancyMini Neuropsychiatric InterviewDiagnosis of depressionImpact of depressionCourse of smokingNon-depressed groupLinear mixed effects regressionSubstance abuse treatmentPerinatal smokingSmoking postpartumBaseline cohortNeuropsychiatric InterviewMixed effects regressionDepressive symptomsSmokingSmoking behaviorDepressive symptomatologyAbuse treatmentPregnancyPostpartum
2012
Depression and Serotonin Reuptake Inhibitor Treatment as Risk Factors for Preterm Birth
Yonkers KA, Norwitz ER, Smith MV, Lockwood CJ, Gotman N, Luchansky E, Lin H, Belanger K. Depression and Serotonin Reuptake Inhibitor Treatment as Risk Factors for Preterm Birth. Epidemiology 2012, 23: 677-685. PMID: 22627901, PMCID: PMC3415566, DOI: 10.1097/ede.0b013e31825838e9.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsMajor depressive episodePreterm birthDepressive episodeLogistic regressionSRI useUse of SRIsSerotonin reuptake inhibitor treatmentReuptake inhibitor treatmentEarly preterm birthLate preterm birthProspective cohort studyPreterm birth riskMajor depressive disorderNominal logistic regressionBinary logistic regressionAntidepressant treatmentCohort studyHospital chartsReuptake inhibitorsSymptomatic womenBirth outcomesPregnant womenRisk factorsDepressive disorderCriteria for Premenstrual Dysphoric Disorder: Secondary Analyses of Relevant Data Sets
Hartlage SA, Freels S, Gotman N, Yonkers K. Criteria for Premenstrual Dysphoric Disorder: Secondary Analyses of Relevant Data Sets. JAMA Psychiatry 2012, 69: 300-305. PMID: 22393222, PMCID: PMC3370334, DOI: 10.1001/archgenpsychiatry.2011.1368.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectFemaleHumansPremenstrual SyndromeProspective StudiesSeverity of Illness IndexConceptsPremenstrual dysphoric disorderDays of mensesDSM-IVPMDD symptomsDysphoric disorderMain outcome measuresOptimal cutoff pointNumber of symptomsSymptomatic periodMenstrual cycleProspective surveyOutcome measuresPerimenstrual symptomsPsychiatric disordersMore symptomsAffective symptomsCutoff pointPhysical symptomsPremenstrual phaseSecondary analysisSymptomsProblematic symptomsClinical settingDepressed moodCohort
2011
Does Antidepressant Use Attenuate the Risk of a Major Depressive Episode in Pregnancy?
Yonkers KA, Gotman N, Smith MV, Forray A, Belanger K, Brunetto WL, Lin H, Burkman RT, Zelop CM, Lockwood CJ. Does Antidepressant Use Attenuate the Risk of a Major Depressive Episode in Pregnancy? Epidemiology 2011, 22: 848-854. PMID: 21900825, PMCID: PMC3188383, DOI: 10.1097/ede.0b013e3182306847.Peer-Reviewed Original ResearchConceptsMajor depressive episodeDepressive episodeAntidepressant useDepressive disorderHigh riskNew major depressive episodesComposite International Diagnostic InterviewDiscontinuation of antidepressantsMajor depressive disorderTime-dependent predictorsAntidepressant medicationAntidepressant treatmentRecurrent illnessAntidepressant discontinuationCox regressionPostpartum womenBlack raceMore episodesObstetrical settingHispanic ethnicityHispanic womenNew episodesPregnancyDiagnostic InterviewAntidepressants
2005
Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study
Bruce SE, Yonkers KA, Otto MW, Eisen JL, Weisberg RB, Pagano M, Shea MT, Keller MB. Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study. American Journal Of Psychiatry 2005, 162: 1179-1187. PMID: 15930067, PMCID: PMC3272761, DOI: 10.1176/appi.ajp.162.6.1179.Peer-Reviewed Original ResearchConceptsComorbid psychiatric disordersClinical courseAnxiety disordersPanic disorderPsychiatric disordersHarvard/Brown Anxiety Disorders Research ProgramLong-term clinical courseProportional hazards regression analysisOverall clinical courseChronic clinical courseHazards regression analysisSocial phobiaComorbid psychiatric conditionsStandard survival analysis methodsGeneralized anxiety disorderLikelihood of recoveryChronic courseProspective studyMulticenter studyPsychiatric comorbidityRisk ratioMajor depressionRecurrencePsychiatric predictorsSurvival analysisPretreatment pattern of symptom expression in premenstrual dysphoric disorder
Pearlstein T, Yonkers KA, Fayyad R, Gillespie JA. Pretreatment pattern of symptom expression in premenstrual dysphoric disorder. Journal Of Affective Disorders 2005, 85: 275-282. PMID: 15780697, DOI: 10.1016/j.jad.2004.10.004.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderPMDD symptomsMenstrual cycleDysphoric disorderPatient variabilityIntermittent dosing strategyOnset of menstruationDSM-IV criteriaPatients' durationAnxiety/tensionSertraline treatmentDRSP scoresPatient daysDosing strategiesSevere symptomsDay 2SymptomsTreatment studiesPretreatment patternAnger/irritabilityMood swingsMore daysWomenSymptom expressionTreatment implications
2003
Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up
Yonkers KA, Bruce SE, Dyck IR, Keller MB. Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up. Depression And Anxiety 2003, 17: 173-179. PMID: 12768651, DOI: 10.1002/da.10106.Peer-Reviewed Original ResearchConceptsHarvard/Brown Anxiety Research ProgramClinical courseRelapse rateUncomplicated panic disorderPanic disorderAnxiety disordersRelapse eventsSex differencesSocial phobiaCumulative remission rateMajority of menFrequent remissionsRemission ratePrognostic implicationsChronic illnessRelapse statusRemissionYears of observationPatientsEnduring illnessSame cohortSignificant sex differencesMonth intervalsIllnessObservation period
2002
Efficacy of intermittent, luteal phase sertraline treatment of premenstrual dysphoric disorder.
Halbreich U, Bergeron R, Yonkers K, Freeman E, Stout A, Cohen L. Efficacy of intermittent, luteal phase sertraline treatment of premenstrual dysphoric disorder. Obstetrics And Gynecology 2002, 100: 1219-29. PMID: 12468166, DOI: 10.1016/s0029-7844(02)02326-8.Peer-Reviewed Original Research
2001
An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women
Yonkers KA, Dyck IR, Keller MB. An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women. Psychiatric Services 2001, 52: 637-643. PMID: 11331798, DOI: 10.1176/appi.ps.52.5.637.Peer-Reviewed Original ResearchConceptsHealth-related qualityHarvard/Brown Anxiety Research ProgramSuicide attemptsSocial phobiaComorbid substance use disorderPoorer baseline functioningLower Global AssessmentPercent of menPercent of womenSubstance use disordersPotential sex differencesComplete remissionRemission rateClinical courseChronic courseEight-year study periodChronic disordersHigh prevalenceObservational studyFunctioning scoresUse disordersBaseline functioningConcurrent agoraphobiaGreater chronicityGlobal assessment