Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV
Abi N, Young A, Tiwari P, Chen J, Liu C, Hui Q, So-Armah K, Freiberg M, Justice A, Xu K, Gwinn M, Marconi V, Sun Y. Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV. Epigenomes 2024, 8: 46. DOI: 10.3390/epigenomes8040046.Peer-Reviewed Original ResearchMethylation risk scoreBody mass indexReduce cardiometabolic disease riskBody mass index associationsMass indexBody mass index varianceRisk of type 2 diabetesVeterans Aging Cohort StudyEpigenome-wide association studiesAnalysis of body mass indexCardiometabolic disease riskAntiretroviral therapyAging Cohort StudyNon-HIV individualsObesity-related risksEpigenome-wide significant CpG-sitesMale PWHLinear mixed modelsTargeted interventionsType 2 diabetesCohort studyDisease riskRisk scorePWHAssociation studiesA multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
Chen J, Hui Q, Titanji B, So-Armah K, Freiberg M, Justice A, Xu K, Zhu X, Gwinn M, Marconi V, Sun Y. A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV. Clinical Epigenetics 2024, 16: 152. PMID: 39488703, PMCID: PMC11531128, DOI: 10.1186/s13148-024-01763-2.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDNA methylationAssociation studiesDNAm sitesDNA methylation sitesAssociated with DNA methylationDNA methylation signaturesInflammatory markersResponse to virusesImmune response to virusesVeterans Aging Cohort StudySignatures of inflammationGenesIdentified sitesAging Cohort StudyInflammation-related genesPathwayPersistent inflammationMale PWHCohort studyExcess morbidityPWHStudy populationInflammationStatistical power