The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clinical Interventions In Aging 2018, 13: 1565-1577. PMID: 30233154, PMCID: PMC6130272, DOI: 10.2147/cia.s160756.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentOlder adultsCognitive impairmentVerbal memoryExecutive functionNeurobiological outcomesNeuropsychological functionNeurobiological mechanismsCognitive functionMental exerciseHealthy agingPilot clinical trialBiomarker measuresClinical trialsPilot dataAdultsSalivary biomarkersImpairmentCognitionFurther researchMemoryPosttrialInadequate dosePreliminary indicationParticipantsBiomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1)
Wall K, Stark J, Karla‐Lall A, Schillaci A, Christian H, Doty C, McLaren E, Saulnier T, Cohen B, Anderson‐Hanley C. Biomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1). The FASEB Journal 2018, 32: 588.25-588.25. DOI: 10.1096/fasebj.2018.32.1_supplement.588.25.Peer-Reviewed Original ResearchMild cognitive impairmentCognitive outcomesCognitive impairmentSignificant cognitive improvementCognitive trainingCognitive interventionsCognitive abilitiesExecutive functionFlanker testCognitive improvementNeurobiological mechanismsSubjects designGame interventionCognitive declineOlder adultsEfficacious interventionsPrior researchStroopSuch interventions