2023
Lessons Learned from the Connecticut Response to COVID-19 in Nursing Homes during the First 2 Years of the Pandemic
Goodwin J, Harizaj A, Armstrong J, Maloney M, Ehrlich H, Leung V, Parikh S. Lessons Learned from the Connecticut Response to COVID-19 in Nursing Homes during the First 2 Years of the Pandemic. Journal Of The American Medical Directors Association 2023, 24: 1573-1578.e1. PMID: 37591486, DOI: 10.1016/j.jamda.2023.07.009.Peer-Reviewed Original ResearchNursing homesSARS-CoV-2-related deathLong-term care facilitiesNursing home residentsPublic healthConnecticut nursing homesPublic health crisisCOVID-19 casesHome residentsCOVID-19 surveillance systemCare facilitiesDeath burdenEarly pandemicLong-term care industryPandemic threatCOVID-19Connecticut DepartmentHealth crisisSurveillance systemInterventionPandemicHealthConnecticut populationHomeVaccine
2022
Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
Mangou K, Moore A, Thiam L, Ba A, Orfanó A, Desamours I, Ndegwa D, Goodwin J, Guo Y, Sheng Z, Patel S, Diallo F, Sene S, Pouye M, Faye A, Thiam A, Nunez V, Diagne C, Sadio B, Shapiro L, Faye O, Mbengue A, Bei A. Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5. Scientific Reports 2022, 12: 19403. PMID: 36371450, PMCID: PMC9653458, DOI: 10.1038/s41598-022-23929-9.Peer-Reviewed Original ResearchConceptsImmune evasionSingle nucleotide polymorphismsPopulation prevalenceVaccine-induced protective immunityP. falciparum positive samplesFalciparum positive samplesPlasmodium falciparum antigensMalaria vaccine candidateNovel single nucleotide polymorphismsInhibitory monoclonal antibodiesProtective immunityFalciparum antigensMalaria deathsEffective vaccineEfficacious vaccineVaccine candidatesPfRH5Infected individualsVaccine targetsMonoclonal antibodiesLow overall frequencyReceptor bindingNovel genetic variantsVaccineOverall frequency