2017
A New Perspective on the Heterogeneity of Cancer Glycolysis
Neugent ML, Goodwin J, Sankaranarayanan I, Yetkin CE, Hsieh MH, Kim JW. A New Perspective on the Heterogeneity of Cancer Glycolysis. Biomolecules & Therapeutics 2017, 26: 10-18. PMID: 29212302, PMCID: PMC5746033, DOI: 10.4062/biomolther.2017.210.Peer-Reviewed Original ResearchGlucose metabolismTumor-associated stromal cellsHuman cancersDynamic metabolic interactionsElevated aerobic glycolysisClinical attemptsMetabolic targetingMolecular alterationsStromal cellsTumor metabolismCancerCentral hallmarkAerobic glycolysisCancer therapyCellular proliferationCancer glycolysisOncogenic signalingMetabolic heterogeneityMetabolismGlycolysisPhysiological functionsMetabolic interactionsMetabolic fluxMetabolic systemsTherapyLung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers
Goodwin J, Neugent ML, Kim JW. Lung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers. Molecular & Cellular Oncology 2017, 4: e1364211. PMID: 29057314, PMCID: PMC5644473, DOI: 10.1080/23723556.2017.1364211.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaCell lung cancerSquamous cell carcinomaCell carcinomaLung cancerGlucose dependencySubtypes of NSCLCGlucose transporter Glut1 expressionLung cancer subtypesLung cancer therapyLung adenocarcinomaGlucose metabolismMajor subtypesCancer subtypesGLUT1 expressionCancer cellsSubtypesCancer therapyCarcinomaCancerMetabolic heterogeneityGlucoseAdenocarcinomaTherapy
2016
NQO1 inhibits proteasome-mediated degradation of HIF-1α
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nature Communications 2016, 7: 13593. PMID: 27966538, PMCID: PMC5171868, DOI: 10.1038/ncomms13593.Peer-Reviewed Original ResearchConceptsHIF-1αColorectal cancer patient survivalNQO1 expression levelsBreast cancer cell linesOverexpression of NQO1HIF-1α expressionCancer patient survivalPro-tumorigenic capacityNQO1 knockdownCancer cell linesPro-tumorigenic functionsPatient survivalPoor prognosisHIF-1α stabilityFunction of NQO1Oxygen-dependent domainHuman colorectalMalignant progressionTumor growthNQO1CancerHIF-1Human cancersMaster transcription factorExpression levels