2024
Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial
dos Santos P, Messina N, de Oliveira R, da Silva P, Puga M, Dalcolmo M, dos Santos G, de Lacerda M, Jardim B, de Almeida e Val F, Curtis N, Andrews J, Croda J. Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial. The Lancet Infectious Diseases 2024, 24: 594-601. PMID: 38423021, PMCID: PMC11111441, DOI: 10.1016/s1473-3099(23)00818-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultBCG VaccineBrazilFemaleHealth PersonnelHumansInterferon-gamma Release TestsMaleMiddle AgedMycobacterium tuberculosisTuberculosis, PulmonaryVaccinationYoung AdultConceptsQuantiFERON-TB GoldPlacebo groupEffect of BCG vaccinationBCG vaccinationBCG groupBCG-DenmarkHealth-care workersNegative baseline resultsMonths of treatmentMycobacterium tuberculosis infectionAdult pulmonary tuberculosisQuantiFERON-TBMedian ageRandomised controlled trialsPulmonary tuberculosisNo significant differenceEfficacy outcomesTuberculosis infectionClinical trialsControlled trialsEffect of vaccinationTreatment drugsTuberculosis preventionSubstudySignificant difference
2020
Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.
Dias de Oliveira R, da Silva Santos A, Reis C, de Cássia Leite A, Correia Sacchi F, de Araujo R, Dos Santos P, Rolla V, Martinez L, Andrews J, Croda J. Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1466-1472. PMID: 32876010, PMCID: PMC7543866, DOI: 10.4269/ajtmh.20-0110.Peer-Reviewed Original ResearchMeSH KeywordsAdultDouble-Blind MethodHumansIncidenceInterferon-gamma Release TestsIsoniazidLatent TuberculosisMycobacterium tuberculosisPrimary PreventionPrisonersPrisonsTuberculin TestTuberculosisYoung AdultConceptsQFT conversionTB infectionSecondary outcomesPlacebo-controlled trialQuantiFERON-TB GoldFuture clinical trialsPrimary prophylaxisMiddle-income countriesPrimary outcomeTuberculosis infectionIntervention armTuberculosis incidenceControl armTrial protocolClinical trialsElevated riskInterim analysisLatent infectionCutoff pointInfectionTrialsHigher cutoffSustained conversionInternational unitsLower rates
2017
Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals
de Oliveira S, Trajman A, Paniago A, Motta-Castro A, Ruffino-Netto A, Maciel E, Croda J, da Gloria Bonecini-Almeida M. Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. Jornal Brasileiro De Pneumologia 2017, 43: 215-218. PMID: 28746533, PMCID: PMC5687953, DOI: 10.1590/s1806-37562016000000125.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBrazilCD4 Lymphocyte CountCross-Sectional StudiesFeasibility StudiesFemaleHumansInfectious Disease Incubation PeriodInterferon-gamma Release TestsLatent TuberculosisMaleMiddle AgedReproducibility of ResultsSurveys and QuestionnairesTuberculin TestConceptsInterferon-gamma releaseIndeterminate resultsHIV/AIDSIGRA resultsTuberculin skin test resultsMultivariate logistic regression modelTuberculin skin testSkin test resultsCost-effectiveness studiesLogistic regression modelsAdvanced immunosuppressionAdjusted ORsSkin testClinical variablesMedical recordsHigh prevalenceHigh riskPatientsIGRARoutine useKappa statisticsPLWHAAIDSRegression modelsKappa