2015
Brain activity classifies adolescents with and without a familial history of substance use disorders
Qiao J, Wang Z, Geronazzo-Alman L, Amsel L, Duarte C, Lee S, Musa G, Long J, He X, Doan T, Hirsch J, Hoven CW. Brain activity classifies adolescents with and without a familial history of substance use disorders. Frontiers In Human Neuroscience 2015, 9: 219. PMID: 25954186, PMCID: PMC4406072, DOI: 10.3389/fnhum.2015.00219.Peer-Reviewed Original ResearchAnterior cingulate cortexSubstance use disordersPrefrontal cortexEmotional conflictBrain circuitsEmotional Stroop taskPotential neurobiological mechanismsFunctional magnetic resonanceUse disordersGroup-level analysisStroop taskVentral tegmental areaNeural substratesCognitive behaviorNeurobiological mechanismsBrain activityEffective connectivityEndophenotype markersCingulate cortexBrain featuresGranger causality indexWeak connectivityFH- adolescentsAdolescentsCausal interactions
2007
Preparatory neural activity predicts performance on a conflict task
Stern ER, Wager TD, Egner T, Hirsch J, Mangels JA. Preparatory neural activity predicts performance on a conflict task. Brain Research 2007, 1176: 92-102. PMID: 17889835, PMCID: PMC2288660, DOI: 10.1016/j.brainres.2007.07.060.Peer-Reviewed Original ResearchConceptsPreparatory neural activityBilateral parietal cortexPreparatory activationNeutral cuesNeural activityParietal cortexRight dorsolateral prefrontal cortexReaction timeSpatial Stroop taskTask-relevant informationConflict resolutionDorsolateral prefrontal cortexTask-specific networksEfficient conflict resolutionConflict stimuliAdvance cuesCueing effectsStroop taskConflict taskAdvance cueingInformative cuesAnterior prefrontalLittle empirical workSemantic cuesPrefrontal cortexSeparate conflict-specific cognitive control mechanisms in the human brain
Egner T, Delano M, Hirsch J. Separate conflict-specific cognitive control mechanisms in the human brain. NeuroImage 2007, 35: 940-948. PMID: 17276088, DOI: 10.1016/j.neuroimage.2006.11.061.Peer-Reviewed Original ResearchConceptsIrrelevant stimulus featuresCognitive controlStimulus featuresModulation of activityColor-naming Stroop taskCognitive control mechanismsCognitive control systemOptimal task performanceHuman brainLevel-dependent responsesContext-sensitive mannerStroop taskResolution of stimuliStimulus representationsTask performanceParietal cortexMotor programmingPremotor cortexInformation processingControl resourcesConflict resolutionSource of conflictResolution strategiesStimuliCentral resource
2005
Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information
Egner T, Hirsch J. Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience 2005, 8: 1784-1790. PMID: 16286928, DOI: 10.1038/nn1594.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBehaviorBrain MappingCerebral CortexCerebrovascular CirculationCognitionConflict, PsychologicalDecision MakingFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuropsychological TestsPattern Recognition, VisualPhotic StimulationPrefrontal CortexReaction TimeVisual CortexVolitionConceptsTask-relevant informationCognitive control mechanismsTask-irrelevant informationCognitive controlTask-relevant stimulus informationCognitive control systemConflict resolutionDorsolateral prefrontal cortexHuman visual cortexAttentional biasingFace processingPerceptual processingFace stimuliStroop taskNeural representationStimulus informationResponse tendenciesOccurrence of conflictsHigh conflictPrefrontal cortexProminent modelsCortical responsesTrial levelCortical amplificationVisual cortexWhere Memory Meets Attention: Neural Substrates of Negative Priming
Egner T, Hirsch J. Where Memory Meets Attention: Neural Substrates of Negative Priming. Journal Of Cognitive Neuroscience 2005, 17: 1774-1784. PMID: 16269113, DOI: 10.1162/089892905774589226.Peer-Reviewed Original ResearchConceptsEpisodic retrievalNegative primingStimulus featuresColor-naming Stroop taskRight dorsolateral prefrontal cortexEpisodic memory retrievalSelective attention performanceMemory retrieval functionsEvent-related fMRICurrent target stimulusSelective attention systemNegative priming effectDorsolateral prefrontal cortexStroop taskAttention systemDistractor stimuliMemory retrievalAttention performanceNeurophysiological predictionsTarget stimuliStimulus informationNeural substratesNeural responsesTheoretical accountsPriming effectThe neural correlates and functional integration of cognitive control in a Stroop task
Egner T, Hirsch J. The neural correlates and functional integration of cognitive control in a Stroop task. NeuroImage 2005, 24: 539-547. PMID: 15627596, DOI: 10.1016/j.neuroimage.2004.09.007.Peer-Reviewed Original ResearchConceptsCognitive controlConflict adaptationPsychophysiological interaction analysisStroop taskNeural correlatesFrontal gyrusPrefrontal cortexDistinct fronto-parietal networksEvent-related fMRI dataLow-conflict trialsHigh-conflict trialsFronto-parietal networkLateral prefrontal cortexMiddle frontal gyrusBilateral inferior frontalSuperior frontal gyrusContext-specific modulationInterference taskResponse conflictCognitive tasksConflict effectMotor processesInferior frontalNeural substratesTask performance